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牙周治疗中最常用抗生素组的副作用。

The Side Effects of the Most Commonly Used Group of Antibiotics in Periodontal Treatments.

作者信息

Heta Saimir, Robo Ilma

机构信息

Pediatric Surgery, University Hospital Center of Tirana, RR. Dibra, 370, Tirana 100, Albania.

Department of Periodontology, Faculty of Medical Sciences, Albanian University, Tirana 1001, Albania.

出版信息

Med Sci (Basel). 2018 Jan 18;6(1):6. doi: 10.3390/medsci6010006.

Abstract

Antibiotic combinations are preferred for the treatment of periodontal diseases, with the aim of hitting the bacterial flora, according to its characteristics-aerobic, anaerobic, gram-negative, and gram-positive-with certain antibiotics that act on certain bacteria. The aim of this study is to analyze the side effects of the antibiotics used. Data on the side effects (preferably expressed in percentages) of some antibiotics, the favorites in periodontal recipes, are gathered from the literature. These data are listed according to the antibiotic used. In the case of providing a periodontal prescription, the patient is at risk of allergy (5%), nephritis (3%), hematological problems (2⁻2.5%), gastrointestinal problems (5.5%), disturbance in the nervous system (2%), allergic signs on the skin (5.5%), and problems with electrolytes displayed in lower percentages. Interaction with different medications is present in almost all cases. The influence on the body systems is 4% in total, the maximum value of which is expressed on the skin, and the minimum value is expressed in the nervous system. Cross allergies are at a high value because of the expressed structural similarity of antibiotics. Given a recipe, we have a balance of the percentage of side effects, the percentage of bacterial resistance, and the percentage of the success of the recommended dose of antibiotics.

摘要

抗生素联合用药是治疗牙周疾病的首选方法,目的是根据细菌菌群的特性——需氧菌、厌氧菌、革兰氏阴性菌和革兰氏阳性菌——使用某些作用于特定细菌的抗生素来抑制细菌群落。本研究的目的是分析所用抗生素的副作用。从文献中收集了一些牙周治疗常用抗生素的副作用数据(最好以百分比表示)。这些数据根据所用抗生素列出。开具牙周治疗处方时,患者有过敏风险(5%)、肾炎风险(3%)、血液学问题风险(2%-2.5%)、胃肠道问题风险(5.5%)、神经系统紊乱风险(2%)、皮肤过敏症状风险(5.5%)以及电解质问题风险(比例较低)。几乎在所有情况下都存在与不同药物的相互作用。对身体系统的影响总计为4%,其中对皮肤的影响最大,对神经系统的影响最小。由于抗生素结构相似性明显,交叉过敏发生率较高。给出一个处方时,我们要综合考虑副作用百分比、细菌耐药性百分比以及推荐剂量抗生素的成功治疗百分比之间的平衡。

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