一种来自海洋腹足纲软体动物 sp. 的新型双-γ-吡喃酮聚丙酯类化合物，属于奥囊素家族。
A new bis-γ-pyrone polypropionate of onchidiol family from marine pulmonate mollusk sp.
机构信息
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China.
Nanjing University of Traditional Chinese Medicine, Nanjing, China.
出版信息
Nat Prod Res. 2020 Jul;34(14):1971-1976. doi: 10.1080/14786419.2019.1569010. Epub 2019 Feb 5.
A new bis-γ-pyrone polypropionate, 4,16-di--onchidiol (), along with three known related compounds (-) were isolated from the marine pulmonate mollusk sp. The structure of compound was elucidated by extensive spectroscopic analysis and by comparison the NMR data with its stereoisomers -, whereas its absolute configuration was determined by the combination of X-ray diffraction analysis and TDDFT-ECD calculation. In bioassay, the isolated compounds exhibited broad cytotoxicity against several cancer cell lines with IC values ranging from 24.6 to 88.5μM.
一种新的双-γ-吡喃酮聚丙酯，4,16-二--onchidiol ()，与三种已知的相关化合物 (-) 一起从海洋腹足纲软体动物 sp. 中分离出来。通过广泛的光谱分析和与立体异构体的 NMR 数据比较，确定了化合物的结构，而其绝对构型则通过 X 射线衍射分析和 TDDFT-ECD 计算相结合来确定。在生物测定中，分离得到的化合物对几种癌细胞系表现出广泛的细胞毒性，IC 值范围为 24.6 至 88.5μM。
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