School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
Bioorg Med Chem Lett. 2021 May 15;40:127921. doi: 10.1016/j.bmcl.2021.127921. Epub 2021 Mar 9.
Five new α-pyrone derivatives, named penpolonin A-E (1-5), together with two known compounds (6-7) were acquired from the endophytic fungus Penicillium polonicum isolated from the roots of Camptotheca acuminata Decne. Their structures were established by combination of NMR and HRESIMS data and the absolute configurations of 1-5 were determined by NMR calculations and comparison of experimental and calculated ECD data. Compounds 3 and 7 exhibited moderate cytotoxicity against Hep-2, TU212 human laryngeal cancer cells with IC values ranging from 31.6 to 45.1 μg/ml, compound 4 showed weak cytotoxicity against the Hep-2 and TU212 cell lines with IC values of 69.2 and 68.7 μg/ml.
从喜树 Camptotheca acuminata Decne 的根部内生真菌 Penicillium polonicum 中分离得到 5 个新的α-吡喃酮衍生物，分别命名为 penpolonin A-E（1-5），以及 2 个已知化合物（6-7）。通过 NMR 和 HRESIMS 数据的组合确定了它们的结构，并通过 NMR 计算和比较实验和计算的 ECD 数据确定了 1-5 的绝对构型。化合物 3 和 7 对 Hep-2、TU212 人喉癌细胞具有中等的细胞毒性，IC 值范围为 31.6-45.1μg/ml，化合物 4 对 Hep-2 和 TU212 细胞系的细胞毒性较弱，IC 值分别为 69.2 和 68.7μg/ml。
