Pesticide and Veterinary Drugs Residue Division, National Institute of Food and Drug Safety Evaluation, Osong, Cheongju, Chungcheongbuk-do, 361-709, Republic of Korea.
CHEM.I.NET Ltd., Room 302, 773-3, Mok-dong, Yangcheon-gu, Seoul, South Korea.
Environ Sci Pollut Res Int. 2019 Mar;26(7):7284-7299. doi: 10.1007/s11356-019-04314-y. Epub 2019 Feb 5.
To ensure public safety against veterinary drug residues in food products from animal sources, maximum residue limits (MRLs) should be established by scientific evidence and a transparent estimation process. The Joint Food and Agriculture Organization (FAO)/World Health Organization (WHO) Expert Committee on Food Additives (JECFA) developed an Excel workbook-based tool for MRLs evaluation in 2003. In this study, we developed a web-based tool for MRL evaluation, called Korean MRL evaluation tools (KMET). While KMET used algorithms of JECFA workbook, it added some databases (e.g., Korean food consumption database) and provided additional functions (e.g., selection of target marker residue). Web-based KMET enabled regulatory policy makers to update the database. All input data and output results related to MRL evaluation based on residue depletion and food consumption datasets were archived and provided overall processes from the initial depletion data entry to MRL establishment with user-friendly interface. Our results demonstrated the stepwise processes whereby MRL for trichlorfon in the muscle of Paralichthys olivaceus was established with functional descriptions of KMET. MRL for trichlorfon derived from KMET was proposed and notified by the Ministry of Food and Drug Safety in 2018.
为确保公众食品安全，防止动物源食品中的兽药残留，应当基于科学证据和透明的评估程序制定最大残留限量（MRLs）。2003 年，粮农组织/世界卫生组织食品添加剂联合专家委员会（JECFA）开发了一个基于 Excel 电子表格的 MRL 评估工具。本研究开发了一个用于 MRL 评估的基于网络的工具，称为韩国 MRL 评估工具（KMET）。虽然 KMET 使用了 JECFA 电子表格的算法，但它增加了一些数据库（例如，韩国食品消费数据库），并提供了一些额外的功能（例如，目标标记残留的选择）。基于网络的 KMET 使监管政策制定者能够更新数据库。所有与残留消除和食品消费数据集相关的 MRL 评估的输入数据和输出结果都被存档，并提供了从初始残留数据输入到 MRL 建立的整个过程，具有用户友好的界面。我们的结果展示了 KMET 的逐步处理过程，即基于功能描述，制定了斜带石斑鱼肌肉中三氯膦的 MRL。2018 年，食品药品安全部提出并通知了 KMET 推导的三氯膦 MRL。
