Department of Pathology, University of Chicago, Chicago, IL, USA.
Department of Pathology, Texas Tech Health Sciences Center, El Paso, TX, USA.
Mod Pathol. 2019 Jun;32(6):732-740. doi: 10.1038/s41379-019-0215-y. Epub 2019 Feb 5.
The diagnostic criteria for chronic myelomonocytic leukemia were recently revised in the 2016 World Health Organization classification update and include new and revised subtypes. In addition, molecular genetic studies have provided new insights into the prognosis and diagnosis of this myeloid neoplasm. This review summarizes the 2016 changes to the diagnostic criteria, discusses potential future changes that may impact diagnosis and provides an overview of recent advances in the diagnosis and prognosis determination of chronic myelomonocytic leukemia.
慢性粒单核细胞白血病的诊断标准最近在 2016 年世界卫生组织分类更新中进行了修订，包括新的和修订的亚型。此外，分子遗传学研究为这种髓系肿瘤的预后和诊断提供了新的见解。本文综述了 2016 年诊断标准的变化，讨论了可能影响诊断的潜在未来变化，并概述了慢性粒单核细胞白血病诊断和预后评估的最新进展。
