Biobehavioral Oncology Program, UPMC Hillman Cancer Center , Pittsburgh, Pennsylvania.
Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Physiology (Bethesda). 2019 Mar 1;34(2):150-162. doi: 10.1152/physiol.00030.2018.
Autonomic nerves are attractive targets for medical therapies using electroceutical devices because of the potential for selective control and few side effects. These devices use novel materials, electrode configurations, stimulation patterns, and closed-loop control to treat heart failure, hypertension, gastrointestinal and bladder diseases, obesity/diabetes, and inflammatory disorders. Critical to progress is a mechanistic understanding of multi-level controls of target organs, disease adaptation, and impact of neuromodulation to restore organ function.
自主神经是电疗设备医学治疗的有吸引力的靶点，因为它具有潜在的选择性控制和很少的副作用。这些设备使用新型材料、电极配置、刺激模式和闭环控制来治疗心力衰竭、高血压、胃肠道和膀胱疾病、肥胖/糖尿病和炎症性疾病。关键是要深入了解目标器官的多层次控制、疾病适应以及神经调节恢复器官功能的影响，从而推动这一领域的进展。
