From the Division of Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina.
Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
Pediatr Infect Dis J. 2019 Jun;38(6):617-619. doi: 10.1097/INF.0000000000002288.
Adolescents living with HIV tend to have poor adherence that often breeds HIV resistance mutations and virologic failure (VF). This study evaluated risk behavior, virologic outcomes and HIV resistance mutations in Tanzanian youth living with HIV. Participants were primarily perinatally infected and of mean age 16.7 years; among them 41.5% had VF. Those receiving first-line therapy demonstrated over 90% resistance to their current therapy.
青少年感染艾滋病毒后往往无法坚持治疗，这往往会导致艾滋病毒耐药突变和病毒学失败 (VF)。本研究评估了坦桑尼亚青少年艾滋病毒感染者的风险行为、病毒学结果和艾滋病毒耐药突变情况。参与者主要是通过母婴传播感染的，平均年龄为 16.7 岁；其中 41.5%的人出现病毒学失败。接受一线治疗的患者对当前治疗的耐药率超过 90%。
