mTOR 是 T 细胞转分化的关键。
mTOR Is Key to T Cell Transdifferentiation.
机构信息
School of Life Sciences and Technology, ShanghaiTech University.
Center for Childhood Cancer and Blood Disease, The Research Institute at Nationwide Children's Hospital, Ohio State University.
出版信息
Cell Metab. 2019 Feb 5;29(2):241-242. doi: 10.1016/j.cmet.2019.01.008.
Abstract
T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.
摘要
T 细胞的转分化为功能不同的亚群在平衡 T 细胞反应的保护和致病特征方面可以发挥关键作用。在一项新的研究中，Karmaus 等人（2019 年）表明，mTORC1 活性影响 T 细胞群体内的代谢异质性，以调节慢性炎症驱动的自身免疫中的转分化和疾病发病机制。
相似文献
1
mTOR Is Key to T Cell Transdifferentiation.mTOR 是 T 细胞转分化的关键。
Cell Metab. 2019 Feb 5;29(2):241-242. doi: 10.1016/j.cmet.2019.01.008.
2
Metabolic heterogeneity underlies reciprocal fates of T17 cell stemness and plasticity.代谢异质性是 T17 细胞干性和可塑性相互转化的基础。
Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19.
3
Context-Specific Function of S6K2 in Th Cell Differentiation.S6K2在辅助性T细胞分化中的特定背景功能。
J Immunol. 2016 Oct 15;197(8):3049-3058. doi: 10.4049/jimmunol.1600167. Epub 2016 Sep 9.
4
Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells.近年来，人们对 Th17 细胞发育和功能的分子机制有了更深入的了解。
Genes Cells. 2013 Apr;18(4):247-65. doi: 10.1111/gtc.12039. Epub 2013 Feb 5.
5
Activation of Mechanistic Target of Rapamycin (mTOR) in Human Endothelial Cells Infected with Pathogenic Spotted Fever Group Rickettsiae.致病性斑点热群立克次体感染的人内皮细胞中雷帕霉素靶蛋白（mTOR）的激活。
Int J Mol Sci. 2020 Sep 29;21(19):7179. doi: 10.3390/ijms21197179.
6
Lamtor1 Is Critically Required for CD4 T Cell Proliferation and Regulatory T Cell Suppressive Function.Lamtor1对于CD4 T细胞增殖和调节性T细胞抑制功能至关重要。
J Immunol. 2017 Sep 15;199(6):2008-2019. doi: 10.4049/jimmunol.1700157. Epub 2017 Aug 2.
7
8
A cellular and molecular view of T helper 17 cell plasticity in autoimmunity.辅助性 T 细胞 17 细胞可塑性在自身免疫中的细胞和分子研究。
J Autoimmun. 2018 Feb;87:1-15. doi: 10.1016/j.jaut.2017.12.007. Epub 2017 Dec 22.
9
mTOR pathway activation in large vessel vasculitis.巨细胞动脉炎中 mTOR 通路的激活。
J Autoimmun. 2018 Nov;94:99-109. doi: 10.1016/j.jaut.2018.07.013. Epub 2018 Jul 27.
10
Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells.同时抑制包含 mTOR 的复合物 1（mTORC1）和 MNK 可诱导皮肤 T 细胞淋巴瘤（CTCL）细胞凋亡。
PLoS One. 2011;6(9):e24849. doi: 10.1371/journal.pone.0024849. Epub 2011 Sep 16.
引用本文的文献
1
Cancer CD39 drives metabolic adaption and mal-differentiation of CD4 T cells in patients with non-small-cell lung cancer.癌症 CD39 驱动非小细胞肺癌患者 CD4 T 细胞的代谢适应和不良分化。
Cell Death Dis. 2023 Dec 8;14(12):804. doi: 10.1038/s41419-023-06336-4.
2
Unveiling Novel Avenues in mTOR-Targeted Therapeutics: Advancements in Glioblastoma Treatment.揭示 mTOR 靶向治疗的新途径：胶质母细胞瘤治疗的进展。
Int J Mol Sci. 2023 Oct 6;24(19):14960. doi: 10.3390/ijms241914960.
3
Cardamonin suppresses pro-tumor function of macrophages by decreasing M2 polarization on ovarian cancer cells via mTOR inhibition.小豆蔻明通过抑制mTOR减少卵巢癌细胞上的M2极化，从而抑制巨噬细胞的促肿瘤功能。
Mol Ther Oncolytics. 2022 Jun 25;26:175-188. doi: 10.1016/j.omto.2022.06.009. eCollection 2022 Sep 15.
4
Deficiency in the Treatment Description of mTOR Inhibitor Resistance in Medulloblastoma, a Systematic Review.《系统评价：成神经管细胞瘤中雷帕霉素靶蛋白抑制剂耐药的治疗描述不足》
Int J Mol Sci. 2021 Dec 31;23(1):464. doi: 10.3390/ijms23010464.
5
Causal Links between Hypovitaminosis D and Dysregulation of the T Cell Connection of Immunity Associated with Obesity and Concomitant Pathologies.维生素D缺乏与肥胖及相关合并症所伴免疫T细胞连接失调之间的因果联系
Biomedicines. 2021 Nov 23;9(12):1750. doi: 10.3390/biomedicines9121750.
6
Overexpressing Kallistatin Aggravates Experimental Autoimmune Uveitis Through Promoting Th17 Differentiation.过表达 Kallistatin 通过促进 Th17 分化加重实验性自身免疫性葡萄膜炎。
Front Immunol. 2021 Oct 18;12:756423. doi: 10.3389/fimmu.2021.756423. eCollection 2021.
7
CD4 T-Cell Plasticity in Non-Infectious Retinal Inflammatory Disease.CD4 T 细胞在非传染性视网膜炎症性疾病中的可塑性。
Int J Mol Sci. 2021 Sep 3;22(17):9584. doi: 10.3390/ijms22179584.
本文引用的文献
1
Metabolic heterogeneity underlies reciprocal fates of T17 cell stemness and plasticity.代谢异质性是 T17 细胞干性和可塑性相互转化的基础。
Nature. 2019 Jan;565(7737):101-105. doi: 10.1038/s41586-018-0806-7. Epub 2018 Dec 19.
2
The dichotomous nature of T helper 17 cells.辅助性 T 细胞 17 细胞的双重性质。
Nat Rev Immunol. 2017 Sep;17(9):535-544. doi: 10.1038/nri.2017.50. Epub 2017 May 30.
3
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes.活化T淋巴细胞分裂后细胞不对称性的代谢维持。
Nature. 2016 Apr 21;532(7599):389-93. doi: 10.1038/nature17442. Epub 2016 Apr 11.
4
Asymmetric inheritance of mTORC1 kinase activity during division dictates CD8(+) T cell differentiation.mTORC1激酶活性在细胞分裂过程中的不对称遗传决定了CD8(+) T细胞的分化。
Nat Immunol. 2016 Jun;17(6):704-11. doi: 10.1038/ni.3438. Epub 2016 Apr 11.
5
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation.在炎症消退过程中，辅助性T细胞17亚群（Th17细胞）可转分化为调节性T细胞。
Nature. 2015 Jul 9;523(7559):221-5. doi: 10.1038/nature14452. Epub 2015 Apr 29.
6
mTOR Links Environmental Signals to T Cell Fate Decisions.mTOR 将环境信号与 T 细胞命运决定联系起来。
Front Immunol. 2015 Jan 20;5:686. doi: 10.3389/fimmu.2014.00686. eCollection 2014.
7
Fate mapping of IL-17-producing T cells in inflammatory responses.在炎症反应中对产生白介素-17 的 T 细胞进行命运图谱分析。
Nat Immunol. 2011 Mar;12(3):255-63. doi: 10.1038/ni.1993. Epub 2011 Jan 30.
8
Genetic proof for the transient nature of the Th17 phenotype.Th17 表型的瞬时性的遗传证据。
Eur J Immunol. 2010 Dec;40(12):3336-46. doi: 10.1002/eji.201040755.
9
Plasticity of CD4+ T cell lineage differentiation.CD4+ T细胞谱系分化的可塑性。
Immunity. 2009 May;30(5):646-55. doi: 10.1016/j.immuni.2009.05.001.
10
An overview of the immune system.免疫系统概述。
Lancet. 2001 Jun 2;357(9270):1777-89. doi: 10.1016/S0140-6736(00)04904-7.
Zotero 插件