Shafeeq Noorhan K
Chemistry Department, College of Education for Pure Science/Ibn Al-Haitham, University of Baghdad, P.O. Box 4150, AI-Adhamiyah/Anter Square/Baghdad, Iraq.
Indian J Clin Biochem. 2019 Jan;34(1):101-107. doi: 10.1007/s12291-017-0717-7. Epub 2017 Nov 14.
In the study, it is aimed to research the likely role of visfatin in hyperthyroid and subclinical hyperthyroid status related to dislipidemia, after determining the visfatin and PON-1 levels thirty healthy individuals were enrolled in this study as control group and thirty hyperthyroidism patient's with dyslipidemia they were treated with. The subjects aged ranged (30-50) years and with BMI (25-29) kg/m. Serum was used in determination of lipid profile total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), thyroid threonine (T3) and thyroxin (T4), thyroid stimulating hormone (TSH), visfatin and paraoxonase-1 (PON-1). The results showed significant increase in T3, T4, TC, TG, LDL and VLDL in patient group when comparing to control group. While significant decrease was found in TSH and HDL in patient group when comparing to control group. The results also represented significant increase in visfatin levels in patient group comparing to control group. While there are significant reducation in PON-1 levels in patient group comparing to control group. The conclusion could be drown from this study that visfatin and PON-1 effected hyperthyroidism patient's with dyslipidemia All the patients in hyperthyroid group were heterozygotes for Familial Hypercholesterolemia is a disorder that is passed down through families. It causes LDL (bad) cholesterol level to be very high. The condition begins at birth and can cause heart attacks at an early age.
在本研究中，旨在研究内脂素在与血脂异常相关的甲状腺功能亢进和亚临床甲状腺功能亢进状态中的可能作用。在测定内脂素和对氧磷酶-1（PON-1）水平后，30名健康个体作为对照组纳入本研究，30名患有血脂异常的甲状腺功能亢进患者接受治疗。受试者年龄在30至50岁之间，体重指数（BMI）为25至29kg/m²。血清用于测定血脂谱，包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、甲状腺素（T3）和甲状腺素（T4）、促甲状腺激素（TSH）、内脂素和对氧磷酶-1（PON-1）。结果显示，与对照组相比，患者组的T3、T4、TC、TG、LDL和VLDL显著升高。与对照组相比，患者组的TSH和HDL显著降低。结果还表明，与对照组相比，患者组的内脂素水平显著升高。而与对照组相比，患者组的PON-1水平显著降低。本研究的结论是，内脂素和PON-1影响患有血脂异常的甲状腺功能亢进患者。甲状腺功能亢进组的所有患者都是家族性高胆固醇血症的杂合子，这是一种通过家族遗传的疾病。它会导致低密度脂蛋白（坏）胆固醇水平非常高。这种情况从出生就开始，可能在早年导致心脏病发作。
