“对氧磷酶-1活性”作为抗氧化剂在冠状动脉疾病中的作用。
The role of 'paraoxonase-1 activity' as an antioxidant in coronary artery diseases.
作者信息
Shekhanawar Maharudra, Shekhanawar Sarala M, Krisnaswamy D, Indumati V, Satishkumar D, Vijay V, Rajeshwari T, Amareshwar M
机构信息
Assistant Professor, Department of Biochemistry Vijayanagar Institute of Medical Sciences Contoment, Bellary-583104, Karnataka, India.
出版信息
J Clin Diagn Res. 2013 Jul;7(7):1284-7. doi: 10.7860/JCDR/2013/5144.3118. Epub 2013 Jul 1.
BACKGROUND AND OBJECTIVES
A majority of the Coronary Artery Diseases (CAD) result from complications of atherosclerosis. There is a growing body of evidence which has revealed that the reduced activity of the HDL-associated enzyme, paraoxonase1 (PON1), is predictive of vascular disease in humans, which include the results from prospective studies. The mechanisms by which PON1 activity influences risk of vascular disease continue to be evaluated. It is generally thought that PON1 contributes to the antioxidant, and thus, to the antiatherogenic properties of High Density Lipoproteins (HDL). Depleted antioxidant levels could be a risk factor for coronary artery disease. Hence, this study was done to evaluate PON1, as antioxidant, in CAD patients.
METHODS
This study was done to determine serum levels of PON1 activity in 50 controls and in 60 clinically and ECG proven CAD cases and to compare PON1 activity with total cholesterol and triglycerides.
RESULTS
Serum levels of PON1 activity (p<0.001) were significantly lower in CAD cases than in controls. Serum total cholesterol (p< 0.001) and triglyceride (p< 0.001) levels were significantly higher in CAD cases than in controls. There was a negative correlation between PON 1 activity and total cholesterol and triglycerides. The negative correlation between PON1 activity and total cholesterol was significant (p<0.05).
INTERPRETATION AND CONCLUSION
From our present study, we can conclude that PON1 can exert a protective effect on HDL by preventing its oxidative damage. Further, a decreased PON 1 activity may be a risk factor for CAD, which is likely to be explained by derangement of PON 1 activity towards lipid peroxidation. This study suggested that serum antioxidant activity of PON1 was an important factor which provided protection from oxidative stress and lipid peroxidation in CAD. Thus, evaluating the effects of PON 1 for CAD patients may be promising in the treatment and prognosis of CAD.
背景与目的
大多数冠状动脉疾病（CAD）由动脉粥样硬化并发症引起。越来越多的证据表明，高密度脂蛋白相关酶对氧磷酶1（PON1）活性降低可预测人类血管疾病，前瞻性研究也得出了类似结果。PON1活性影响血管疾病风险的机制仍在评估中。一般认为，PON1具有抗氧化作用，因此对高密度脂蛋白（HDL）的抗动脉粥样硬化特性有贡献。抗氧化水平降低可能是冠状动脉疾病的一个危险因素。因此，本研究旨在评估CAD患者中作为抗氧化剂的PON1。
方法
本研究旨在测定50名对照者和60名经临床及心电图证实的CAD患者的血清PON1活性水平，并将PON1活性与总胆固醇和甘油三酯进行比较。
结果
CAD患者的血清PON1活性水平（p<0.001）显著低于对照组。CAD患者的血清总胆固醇（p<0.001）和甘油三酯（p<0.001）水平显著高于对照组。PON1活性与总胆固醇和甘油三酯之间呈负相关。PON1活性与总胆固醇之间的负相关具有显著性（p<0.05）。
解读与结论
从我们目前的研究可以得出结论，PON1可通过防止HDL的氧化损伤对其发挥保护作用。此外，PON1活性降低可能是CAD的一个危险因素，这可能是由于PON1活性对脂质过氧化的紊乱所致。本研究表明，PON1的血清抗氧化活性是CAD中提供抗氧化应激和脂质过氧化保护的重要因素。因此，评估PON1对CAD患者的影响可能对CAD的治疗和预后具有前景。
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