Malinowski Bartosz, Węsierska Anna, Zalewska Klaudia, Sokołowska Maya M, Bursiewicz Wiktor, Socha Maciej, Ozorowski Mateusz, Pawlak-Osińska Katarzyna, Wiciński Michał
1Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.
3Department of Obstetrics, Gynecology and Gynecological Oncology, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Ujejskiego 75, 85-168 Bydgoszcz, Poland.
Infect Agent Cancer. 2019 Jan 30;14:3. doi: 10.1186/s13027-019-0220-2. eCollection 2019.
and are anaerobic Gram-negative bacterial species which have been implicated in periodontal diseases as a part of red complex of periodontal pathogens. Esophageal cancer is the eight most common cause of cancer deaths worldwide. Higher rates of esophageal cancer cases may be attributed to lifestyle factors such as: diet, obesity, alcohol and tobacco use. Moreover, the presence of oral and has been found to be associated with an increased risk of esophageal cancer. Our review describes the role of and in signaling pathways responsible for cancer development. It has been shown that may induce pro-inflammatory cytokines such as IL-1β and IL-6 by CD4 + T helper cells and TNF-α. Moreover, gingipain K produced by affects hosts immune system by degradation of immunoglobulins and complement system (C3 and C5 components). Discussed bacteria are responsible for overexpression of MMP-2, MMP-2 and GLUT transporters.
[具体细菌名称1]和[具体细菌名称2]是厌氧革兰氏阴性菌，作为牙周病原体红色复合体的一部分，与牙周疾病有关。食管癌是全球第八大常见癌症死亡原因。较高的食管癌发病率可能归因于生活方式因素，如饮食、肥胖、饮酒和吸烟。此外，已发现口腔中[具体细菌名称1]和[具体细菌名称2]的存在与食管癌风险增加有关。我们的综述描述了[具体细菌名称1]和[具体细菌名称2]在负责癌症发展的信号通路中的作用。研究表明，[具体细菌名称1]可能通过CD4 + T辅助细胞诱导促炎细胞因子，如IL-1β、IL-6和TNF-α。此外，[具体细菌名称2]产生的牙龈蛋白酶K通过降解免疫球蛋白和补体系统（C3和C5成分）影响宿主免疫系统。所讨论的细菌导致MMP-2、MMP-2和GLUT转运蛋白的过度表达。
