Jung Chanyong, Kim Sangwan, Sun Taeuk, Cho Yong-Bum, Song Minju
Department of Dentistry, Aerospace Medical Center, Cheongju, Korea.
Department of Conservative Dentistry, College of Dentistry, Dankook University, Cheonan, Korea.
J Tissue Eng. 2019 Jan 29;10:2041731418819263. doi: 10.1177/2041731418819263. eCollection 2019 Jan-Dec.
Regenerative endodontic procedures for immature permanent teeth with apical periodontitis confer biological advantages such as tooth homeostasis, enhanced immune defense system, and a functional pulp-dentin complex, in addition to clinical advantages such as the facilitation of root development. Currently, this procedure is recognized as a paradigm shift from restoration using materials to regenerate pulp-dentin tissues. Many studies have been conducted with regard to stem/progenitor cells, scaffolds, and biomolecules, associated with pulp tissue engineering. However, preclinical and clinical studies have evidently revealed several drawbacks in the current clinical approach to revascularization that may lead to unfavorable outcomes. Therefore, our review examines the challenges encountered under clinical conditions and summarizes current research findings in an attempt to provide direction for transition from basic research to clinical practice.
针对患有根尖周炎的年轻恒牙的再生牙髓治疗程序具有生物学优势，如牙齿内环境稳定、增强免疫防御系统以及功能性牙髓-牙本质复合体，此外还具有临床优势，如促进牙根发育。目前，该治疗程序被认为是从使用材料进行修复到再生牙髓-牙本质组织的范式转变。关于与牙髓组织工程相关的干细胞/祖细胞、支架和生物分子，已经开展了许多研究。然而，临床前和临床研究明显揭示了当前临床再血管化方法中的几个缺点，这些缺点可能导致不良后果。因此，我们的综述探讨了临床条件下遇到的挑战，并总结了当前的研究结果，试图为从基础研究向临床实践的转变提供指导。
