Obonyo Nchafatso Gikenyi, Schlapbach Luregn Jan, Fraser John Francis
IDeAL/KEMRI-Wellcome Trust Research Programme, CGMRC, Kilifi, Kenya.
Critical Care Research Group, The Prince Charles Hospital, Chermside, QLD, Australia.
Front Pediatr. 2019 Jan 23;6:425. doi: 10.3389/fped.2018.00425. eCollection 2018.
The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial proportion of mortality globally, especially amongst children in low-and-middle income country settings. It is therefore urgent to develop and validate standardized criteria for sepsis that can be applied to pediatric populations in different settings, including in- and outside intensive care, both in high- and low/middle- income countries. This will be a pre-requisite to evaluate the impact of sepsis treatment strategies to improve clinical outcomes.
最近修订的脓毒症-3定义所依据的标准是在高收入国家的成人患者数据库中得出并验证的。脓毒症和脓毒性休克在全球范围内仍占相当大比例的死亡率，尤其是在低收入和中等收入国家环境中的儿童中。因此，迫切需要制定和验证适用于不同环境下儿科人群的脓毒症标准化标准，包括高收入国家和低/中等收入国家重症监护室内外。这将是评估脓毒症治疗策略对改善临床结局影响的先决条件。
