Department of Gastroenterology, Institute of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032 Debrecen, Hungary.
Department of Infectology, Faculty of Medicine, University of Debrecen, Bartok B. u. 2-26, 4031 Debrecen, Hungary.
Biomed Res Int. 2019 Jan 8;2019:8310583. doi: 10.1155/2019/8310583. eCollection 2019.
To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups.
39 patients with Crohn's disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject.
The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF- inhibitor use.
Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.
评估炎症性肠病（IBD）各亚组中干眼疾病（DED）的泪膜参数及客观临床体征与主观症状的关系。
本前瞻性病例对照和横断面研究纳入 39 例克罗恩病（CD）患者、26 例溃疡性结肠炎（UC）患者和 39 例无眼部症状或表面疾病的对照者。采用眼表疾病指数（OSDI）问卷评估干眼症状，并对所有受试者的双眼进行 DED 的客观检查。
CD 患者的 OSDI 平均得分为 30.59（±16.68），UC 患者为 24.67（±23.48），对照组为 11.19（±5.8）。除泪膜破裂时间（tBUT）和 Schirmer-I 值外，UC 患者的其他客观参数均优于 CD 患者。CD 患者而非 UC 患者更易发生 DED，这与免疫抑制剂和 TNF-α抑制剂的使用有关。
临床医生必须意识到 IBD 中 DED 的涉及范围，并建议使用人工泪液以降低眼部并发症的严重程度。
