Szymczyk Beata, Szczurek Witold, Świątkiewicz Sylwester, Kwiatek Krzysztof, Sieradzki Zbigniew, Mazur Małgorzata, Bednarek Dariusz, Reichert Michał
Department of Nutrition Physiology, National Research Institute of Animal Production, 32-083 Balice, Poland.
Department of Hygiene of Animal Feedingstuffs, 24-100 Pulawy, Poland.
J Vet Res. 2018 Dec 31;62(4):555-561. doi: 10.2478/jvetres-2018-0060. eCollection 2018 Dec.
The influence of feeding genetically modified MON 810 hybrid maize on the growth and haematological and biochemical indices of rats was tested.
Two conventional (non-GM) and two test (MON 810) lines of maize were used in semi-purified diets at the level of 40% w/w. The non-GM I, MON 810 I, non-GM II, and MON 810 II maize lines were near-isogenic. A total of 40 male 6-week-old Wistar-derived rats were assigned to four equal feeding groups corresponding to the four maize lines for 16 weeks. Overall, health, body weight gain, clinical pathology parameters, gross changes, and appearance of tissues were compared between groups.
There were no statistically significant differences in the weight gain or relative organ weights of rats, but there were some non diet-related histopathological changes in the liver, kidneys, and spleen. Except for creatinine level, no diet-related effects were observed in haematology or most of the biochemical indices. Transgenic DNA of MON 810 maize was not detected in the tissues or faeces nor in the DNA of isolated from the rectum digesta of rats given transgenic feeds. In our experiment, various metabolic indices of rats fed non-GM diets or genetically modified (MON 810) maize for 16 weeks were similar. No adverse nutrition-related health effects were detected.
MON 810 maize seems to be as safe as the conventional maize lines.
测试了喂食转基因MON 810杂交玉米对大鼠生长、血液学和生化指标的影响。
两种常规（非转基因）和两种测试（MON 810）玉米品系以40%（w/w）的水平用于半纯化日粮。非转基因I、MON 810 I、非转基因II和MON 810 II玉米品系为近等基因系。将总共40只6周龄的雄性Wistar衍生大鼠分配到四个相等的喂食组，分别对应四种玉米品系，为期16周。总体而言，比较了各组之间的健康状况、体重增加、临床病理学参数、大体变化和组织外观。
大鼠的体重增加或相对器官重量没有统计学上的显著差异，但肝脏、肾脏和脾脏出现了一些与饮食无关的组织病理学变化。除肌酐水平外，在血液学或大多数生化指标中未观察到与饮食相关的影响。在喂食转基因饲料的大鼠的组织、粪便或从直肠消化物中分离的DNA中均未检测到MON 810玉米的转基因DNA。在我们的实验中，喂食非转基因日粮或转基因（MON 810）玉米16周的大鼠的各种代谢指标相似。未检测到与营养相关的不良健康影响。
MON 810玉米似乎与常规玉米品系一样安全。
