Jefferis Joanna M, Hickman Simon J
Department of Ophthalmology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
Department of Neurology, Royal Hallamshire Hospital, Sheffield, UK.
Curr Treat Options Neurol. 2019 Feb 7;21(1):5. doi: 10.1007/s11940-019-0542-9.
Nutritional optic neuropathy is a potential cause of severe visual loss; however, appropriate and timely management can result in excellent visual outcomes. The purpose of this review is to outline our current understanding of the treatment and outcomes for nutritional optic neuropathy.
Current understanding of nutritional optic neuropathy has been greatly aided by some well-reported and investigated epidemics of the condition, most notably the Cuban epidemic optic neuropathy of the early 1990s. More recently, there is an emerging literature surrounding nutritional deficiencies that can occur in patients who have undergone bariatric surgery. There also continues to be a stream of case reports in the literature that add to our understanding. Nutritional optic neuropathy has a great deal of overlap with toxic optic neuropathies and hereditary optic neuropathies and should not be thought of in isolation from these conditions. The mainstay of treatment for nutritional optic neuropathy involves identifying and replacing deficient nutrients as well as identifying and eliminating contributory toxins. It is also important to identify contributory genetic factors and to consider the broader social, economic and societal factors which may contribute.
营养性视神经病变是严重视力丧失的一个潜在原因;然而,恰当且及时的治疗可带来良好的视力预后。本综述的目的是概述我们目前对营养性视神经病变治疗及预后的理解。
一些对该病症进行了充分报道和研究的流行病,尤其是20世纪90年代初的古巴流行性视神经病变,极大地促进了我们目前对营养性视神经病变的理解。最近,围绕接受减肥手术患者可能出现的营养缺乏,出现了越来越多的文献。文献中也不断有病例报告,增进了我们的认识。营养性视神经病变与中毒性视神经病变和遗传性视神经病变有很多重叠之处,不应孤立地看待这种病症。营养性视神经病变的主要治疗方法包括识别和补充缺乏的营养素,以及识别和消除促成毒素。识别促成的遗传因素并考虑可能起作用的更广泛的社会、经济和社会因素也很重要。