Thompson Austen L, Largent-Milnes Tally M, Vanderah Todd W
Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
Methods Mol Biol. 2019;1914:391-407. doi: 10.1007/978-1-4939-8997-3_23.
Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control. Pain originating in the bone can be caused by many different entities including metastatic and primary neoplasm, fracture, osteoarthritis as well as numerous other metabolic disorders. In this chapter we describe the methods and protocols that currently are accepted and validated for the study of bone pain in models of metastatic cancer, bicortical fracture and osteoarthritis. These animal models provide invaluable information as to the nature of bone pain and give rise to potential new targets for its treatment and management.
骨痛是当今社会普遍存在的问题，也是最难控制的疼痛类型之一。源于骨骼的疼痛可能由许多不同的病因引起，包括转移性和原发性肿瘤、骨折、骨关节炎以及许多其他代谢紊乱。在本章中，我们描述了目前在转移性癌症、双侧皮质骨折和骨关节炎模型中用于研究骨痛的已被接受和验证的方法与方案。这些动物模型为骨痛的本质提供了宝贵的信息，并为其治疗和管理带来了潜在的新靶点。
