干细胞疗法的最新进展：聚焦癌症、帕金森病和阿尔茨海默病。
Recent advances in stem cells therapy: A focus on cancer, Parkinson's and Alzheimer's.
作者信息
Fleifel Dalia, Rahmoon Mai Atef, AlOkda Abdelrahman, Nasr Mostafa, Elserafy Menattallah, El-Khamisy Sherif F
机构信息
Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Ahmed Zewail Road, October Gardens, 6th of October City, Giza 12578, Egypt.
Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, S10 2TN Sheffield, UK.
出版信息
J Genet Eng Biotechnol. 2018 Dec;16(2):427-432. doi: 10.1016/j.jgeb.2018.09.002. Epub 2018 Dec 10.
Abstract
Stem cells serve as potential therapeutics due to their high proliferative capacity, low immunogenic reactivity and their differentiating capabilities. Several pre-clinical and early-stage clinical studies are carried out to treat genetic diseases, cancers and neurodegenerative disorders with promising preliminary results. However, there are still many challenges that scientists are trying to overcome such as the unclear expression profile of stem cells the homing of stem cells to the site of injury and their potential immune-reactivity. Prospective research lies in gene editing of autologous stem cells and safe injection of these modified cells back into patients. Here, we review the clinical trials executed using stem cell therapy in an attempt to cure challenging diseases like cancer, Parkinson's and Alzheimer's diseases.
摘要
干细胞因其高增殖能力、低免疫反应性和分化能力而成为潜在的治疗手段。目前已开展了多项临床前和早期临床研究，用于治疗遗传疾病、癌症和神经退行性疾病，并取得了初步的积极成果。然而，科学家们仍在努力克服许多挑战，例如干细胞表达谱不明确、干细胞归巢至损伤部位以及它们潜在的免疫反应性。未来的研究方向在于对自体干细胞进行基因编辑，并将这些经过修饰的细胞安全地回输到患者体内。在此，我们综述了使用干细胞疗法进行的临床试验，旨在治疗如癌症、帕金森病和阿尔茨海默病等疑难病症。
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