CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
College of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2019 Mar;8(5):e1801591. doi: 10.1002/adhm.201801591. Epub 2019 Feb 8.
Herein, a simple, effective, and general strategy is demonstrated to obtain a water-soluble and nontoxic cellulose-based photosensitizer (CPS) with enhanced photodynamic antibacterial activity through introducing protoporphyrin IX (PpIX) and quaternary ammonium salt (QAS) groups onto the cellulose backbone. The synergistic effect of the anchoring and diluting effect of the cellulose backbone and the electrostatic repulsion between QAS groups effectively inhibit the π-π stacking of PpIX groups, thus the as-prepared CPS exhibits markedly enhanced reactive oxygen species (ROS) yield. Meanwhile, the positively charged QAS groups endow the CPS with water-solubility and a strong attractive force to bacteria. As a result, the CPS can rapidly and efficiently kill drug-resistant bacteria strains, including E. coli and S. aureus, with a low light dose (2.4 J cm ) and low concentration of PpIX groups (0.35 × 10 m). Benefiting from the excellent processability and formability, the CPS is readily applied as a sunlight-driven wearable and robust antibacterial coating by a spray coating and later crosslinking procedure.
本文展示了一种简单、有效且通用的策略，通过在纤维素主链上引入原卟啉 IX（PpIX）和季铵盐（QAS）基团，获得了一种水溶性和无毒的基于纤维素的光敏剂（CPS），具有增强的光动力抗菌活性。纤维素主链的锚固和稀释效应以及 QAS 基团之间的静电排斥的协同作用，有效地抑制了 PpIX 基团的π-π堆积，从而使制备的 CPS 表现出明显增强的活性氧（ROS）产率。同时，带正电荷的 QAS 基团赋予 CPS 水溶性和对细菌的强吸引力。因此，CPS 可以在低光剂量（2.4 J cm ）和低 PpIX 浓度（0.35 × 10 ）下，快速有效地杀死包括大肠杆菌和金黄色葡萄球菌在内的耐药菌菌株。得益于优异的可加工性和可成型性，CPS 可通过喷涂和随后的交联程序，很容易地用作阳光驱动的可穿戴式和坚固的抗菌涂层。
