Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Analyst. 2019 Mar 11;144(6):1866-1875. doi: 10.1039/c8an02421a.
A keloid is a type of unusually raised scar. Unlike other raised scars, keloids form larger sizes than the wound site due to overgrowth, generally related to various biological factors. To date, only a few diagnostic and therapeutic methods for keloids have been reported. The high recurrence rates and undesirable side effects of keloids, at the end stage, encourage the invention of novel diagnostic tools, in order to cure keloids at an earlier stage. In this review, we summarize the general information about keloid diagnosis, keloid biomarkers, and recently reported fluorescent probes that can sense the key biomarkers of keloids. The focused description of fluorescent probes for keloid biomarkers and the author's perspective give useful insights in order to design the next-generation diagnostic sensing system for keloids.
瘢痕疙瘩是一种异常隆起的疤痕。与其他隆起的疤痕不同，由于过度生长，瘢痕疙瘩的大小通常比创伤部位大，这与各种生物因素有关。迄今为止，只有少数几种瘢痕疙瘩的诊断和治疗方法被报道。由于瘢痕疙瘩的高复发率和不理想的副作用，在晚期阶段，鼓励发明新的诊断工具，以便在早期阶段治愈瘢痕疙瘩。在这篇综述中，我们总结了有关瘢痕疙瘩诊断、瘢痕疙瘩生物标志物以及最近报道的可检测瘢痕疙瘩关键生物标志物的荧光探针的一般信息。对用于瘢痕疙瘩生物标志物的荧光探针的重点描述以及作者的观点提供了有用的见解，以便为下一代瘢痕疙瘩诊断传感系统设计提供思路。
