Department of Chemistry and Pharmacy , University of Sassari , 07100 Sassari , Italy.
Department of Life and Environmental Sciences , University of Cagliari , 09042 Cagliari , Italy.
J Med Chem. 2019 Jul 11;62(13):5923-5943. doi: 10.1021/acs.jmedchem.8b01439. Epub 2019 Feb 21.
Silver has no biological role, and it is particularly toxic to lower organisms. Although several silver formulations employed in medicine in the past century are prescribed and sold to treat certain medical conditions, most of the compounds, including those showing outstanding properties as antimicrobial or anticancer agents, are still in early stages of assessment, that is, in vitro studies, and may not make it to clinical trials. Unlike other heavy metals, there is no evidence that silver is a cumulative poison, but its levels can build up in the body tissues after prolonged exposure leading to undesired effects. In this review, we deal with the journey of silver in medicine going from the alternative or do-it-yourself drug to scientific evidence related to its uses. The many controversies push scientists to move toward a more comprehensive understanding of the mechanisms involved.
银没有生物学作用，对低等生物特别有毒。虽然过去一个世纪中在医学中使用的几种银制剂被规定并销售来治疗某些医疗状况，但大多数化合物，包括那些表现出作为抗菌或抗癌剂的杰出性质的化合物，仍处于评估的早期阶段，即体外研究，并且可能无法进行临床试验。与其他重金属不同，没有证据表明银是一种累积性毒物，但在长期暴露后，其水平会在体内组织中积累，导致不良影响。在这篇综述中，我们讨论了银在医学中的发展历程，从替代药物或自己动手的药物到与用途相关的科学证据。许多争议促使科学家们更全面地了解所涉及的机制。
