Wang Qiusheng, Han Guocong, Yan Shuqin, Zhang Qiang
Key Laboratory of Textile Fiber & Product (Ministry of Education), School of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Materials (Basel). 2019 Feb 6;12(3):504. doi: 10.3390/ma12030504.
Three-dimensional (3D) printing is regarded as a critical technological-evolution in material engineering, especially for customized biomedicine. However, a big challenge that hinders the 3D printing technique applied in biomedical field is applicable bioink. Silk fibroin (SF) is used as a biomaterial for decades due to its remarkable high machinability and good biocompatibility and biodegradability, which provides a possible alternate of bioink for 3D printing. In this review, we summarize the requirements, characteristics and processabilities of SF bioink, in particular, focusing on the printing possibilities and capabilities of bioink. Further, the current achievements of cell-loading SF based bioinks were comprehensively viewed from their physical properties, chemical components, and bioactivities as well. Finally, the emerging issues and prospects of SF based bioink for 3D printing are given. This review provides a reference for the programmable and multiple processes and the further improvement of silk-based biomaterials fabrication by 3D printing.
三维（3D）打印被视为材料工程领域的一项关键技术革新，尤其在定制化生物医学方面。然而，阻碍3D打印技术应用于生物医学领域的一个巨大挑战是适用的生物墨水。由于丝素蛋白（SF）具有卓越的高加工性、良好的生物相容性和生物降解性，几十年来一直被用作生物材料，这为3D打印生物墨水提供了一种可能的替代物。在这篇综述中，我们总结了SF生物墨水的要求、特性和可加工性，尤其关注生物墨水的打印可能性和能力。此外，还从其物理性质、化学成分和生物活性等方面全面审视了基于负载细胞的SF生物墨水的当前研究成果。最后，给出了基于SF的3D打印生物墨水的新出现问题和前景。本综述为3D打印的可编程和多流程以及基于丝绸的生物材料制造的进一步改进提供了参考。
