Jose Rod R, Brown Joseph E, Polido Katherine E, Omenetto Fiorenzo G, Kaplan David L
Department of Biomedical Engineering, Tufts University Science and Technology, Center 4 Colby Street, Medford, Massachusetts 02155, United States.
ACS Biomater Sci Eng. 2015 Sep 14;1(9):780-788. doi: 10.1021/acsbiomaterials.5b00160. Epub 2015 Aug 14.
Silk-based bioinks were developed for 2D and 3D printing. By incorporating nontoxic polyols into silk solutions, two-part formulations with self-curing features at room temperature were generated. By varying the formulations the crystallinity of the silk polymer matrix could be controlled to support printing in 2D and 3D formats interfaced with CAD geometry and with good feature resolution. The self-curing phenomenon was tuned and exploited in order to demonstrate the formation of both structural and support materials. Biocompatible aqueous protein inks for printing that avoid the need for chemical or photo initiators and that form aqueous-stable structures with good resolution at ambient temperatures provide useful options for biofunctionalization and a broad range of applications.
基于丝绸的生物墨水被开发用于二维和三维打印。通过将无毒多元醇加入丝绸溶液中，生成了具有室温自固化特性的双组分配方。通过改变配方，可以控制丝绸聚合物基质的结晶度，以支持与CAD几何形状接口且具有良好特征分辨率的二维和三维格式打印。对自固化现象进行了调整和利用，以证明结构材料和支撑材料的形成。用于打印的生物相容性水性蛋白质墨水无需化学或光引发剂，并且在环境温度下能形成具有良好分辨率的水稳定结构，为生物功能化和广泛应用提供了有用的选择。
