Eslami Parisa, Rossi Filippo, Fedeli Stefano
Laboratory of Molecular Magnetism (LaMM), Department of Chemistry "Ugo Shiff", University of Florence, via della Lastruccia 3, 50019, Sesto Fiorentino, Italy.
Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, 20131 Milano, Italy.
Pharmaceutics. 2019 Feb 7;11(2):71. doi: 10.3390/pharmaceutics11020071.
Considering nanogels, we have focused our attention on hybrid nanosystems for drug delivery and biomedical purposes. The distinctive strength of these structures is the capability to join the properties of nanosystems with the polymeric structures, where versatility is strongly demanded for biomedical applications. Alongside with the therapeutic effect, a non-secondary requirement of the nanosystem is indeed its biocompatibility. The importance to fulfill this aim is not only driven by the priority to reduce, as much as possible, the inflammatory or the immune response of the organism, but also by the need to improve circulation lifetime, biodistribution, and bioavailability of the carried drugs. In this framework, we have therefore gathered the hybrid nanogels specifically designed to increase their biocompatibility, evade the recognition by the immune system, and overcome the self-defense mechanisms present in the bloodstream of the host organism. The works have been essentially organized according to the hybrid morphologies and to the strategies adopted to fulfill these aims: Nanogels combined with nanoparticles or with liposomes, and involving polyethylene glycol chains or zwitterionic polymers.
考虑到纳米凝胶，我们将注意力集中在用于药物递送和生物医学目的的混合纳米系统上。这些结构的独特优势在于能够将纳米系统的特性与聚合物结构相结合，而生物医学应用强烈需要这种多功能性。除了治疗效果外，纳米系统的一个重要要求确实是其生物相容性。实现这一目标的重要性不仅在于尽可能降低机体炎症或免疫反应的首要任务，还在于提高所携带药物的循环寿命、生物分布和生物利用度的需要。在此框架下，我们收集了专门设计用于提高其生物相容性、逃避免疫系统识别并克服宿主生物体血液中存在的自我防御机制的混合纳米凝胶。这些研究基本上是根据混合形态以及为实现这些目标所采用的策略进行组织的：纳米凝胶与纳米颗粒或脂质体结合，并涉及聚乙二醇链或两性离子聚合物。
