Department of Applied Oral Sciences, Forsyth Institute, Harvard School of Dental Medicine Affiliate, Cambridge, MA, USA.
Department of Applied Oral Sciences, Forsyth Institute, Harvard School of Dental Medicine Affiliate, Cambridge, MA, USA; College of Advancing & Professional Studies (CAPS), University of Massachusetts Boston (UMB), Boston, MA, USA; Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USA.
J Steroid Biochem Mol Biol. 2019 Apr;188:166-171. doi: 10.1016/j.jsbmb.2019.01.023. Epub 2019 Feb 8.
Phosphates are associated with numerous disorders, ranging from vascular calcification to premature aging, possibly because of an increased inflammatory response. We therefore investigated the association of dietary phosphorus with gingivitis. We analyzed consumption of both phosphorus and sugar and related it to the concentrations of inflammatory biomarkers in saliva samples collected from 8314 children (mean age, 9.99 ± 0.68 years). About 64% of the children consumed more than 1250 mg phosphorus daily, and 34% consumed more than 82 g of sugar daily. Gingivitis was prevalent, with an average of 74% of possible gingival sites considered red. Quantile regression analysis revealed a statistically significant correlation between the occurrence of gingivitis and calorie-adjusted phosphorus intake and between gingivitis and calorie-adjusted sugar intake (both significant either as a linear trend or a categorical variable). In a subset (n = 744) investigation of nutrient consumption related to salivary biomarkers, we found that elevated calorie-adjusted phosphorus intake was directly associated with salivary IL-1β concentration (OR1.40, 95% CI 1.04-1.89), and inversely associated with salivary IL-4 concentration (OR0.62, 95% CI 0.46-0.84). Sugar intake was not significantly associated with either biomarker. Thus, elevated dietary phosphorus consumption may influence inflammatory disease by altering cytokine levels.
磷与许多疾病有关，从血管钙化到早衰，可能是因为炎症反应增加。因此，我们研究了饮食磷与牙龈炎的关系。我们分析了磷和糖的摄入量，并将其与从 8314 名儿童（平均年龄 9.99±0.68 岁）的唾液样本中收集的炎症生物标志物的浓度相关联。大约 64%的儿童每天摄入的磷超过 1250mg，34%的儿童每天摄入的糖超过 82g。牙龈炎很普遍，平均有 74%的可能牙龈部位被认为是红色的。分位数回归分析显示，牙龈炎的发生与经热量调整的磷摄入量之间以及牙龈炎与经热量调整的糖摄入量之间存在统计学上的显著相关性（两者无论是作为线性趋势还是分类变量都是显著的）。在对与唾液生物标志物相关的营养物质摄入的子样本（n=744）调查中，我们发现，经热量调整的磷摄入量增加与唾液中 IL-1β浓度直接相关（OR1.40，95%CI 1.04-1.89），与唾液中 IL-4 浓度呈负相关（OR0.62，95%CI 0.46-0.84）。糖的摄入量与这两种生物标志物均无显著相关性。因此，饮食中磷的摄入量增加可能通过改变细胞因子水平来影响炎症性疾病。
