Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA.
Unit of Pharmacology, Faculty of Medicine and Defense Health, National Defense University of Malaysia, Kuala Lumpur 57000, Malaysia.
Nutrients. 2022 Oct 25;14(21):4477. doi: 10.3390/nu14214477.
Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual's risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.
磷是人体内含量最丰富的矿物质之一。它通过形成 ATP、细胞内信号转导、细胞膜形成、骨矿化、DNA 和 RNA 合成以及通过各种炎症细胞因子调节炎症，对几乎所有生化活动都是必不可少的。磷水平必须得到最佳调节，因为任何偏差都可能导致葡萄糖稳态的严重紊乱。临床研究报告称，高磷血症会增加个体患代谢综合征的风险。高磷酸盐负荷已被证明通过损害胰腺胰岛素分泌和增加心脏代谢紊乱的风险来损害葡萄糖代谢。由于代谢综合征在全球范围内越来越常见，因此应该进一步研究以确定磷酸盐负荷如何增加普通人群中心血管代谢风险的潜在机制，因此应该更加关注磷酸盐毒性。
