Jebur Hakim Bahlok, Masroor Mirza, Ahmad Hafiz, Khan Naushad Ahmad, Akther Juheb, Bharali Dipu, Singh Vijay Kumar, Verma Amit, Khan Shahbaz, Khan Vasiuddin, Hasan Rameez, Bhatt Deepti, Goyal Yamini, Dev Kapil
Deparment of Pharmacology, Faculty of Medicine, WAIST University, Iraq.
Deparment of Medical Elementology and Toxicology, Jamia Hamdard, New Delhi, India.
Open Access Maced J Med Sci. 2018 Dec 11;7(1):33-37. doi: 10.3889/oamjms.2019.014. eCollection 2019 Jan 15.
C-reactive protein (CRP) is an inflammatory marker associated with T2DM, obesity, insulin resistance, and cardiovascular disease.
The present study evaluates the association of CRP +1059 G/C polymorphism of the gene in 100 T2D cases and 100 healthy controls.
Present study was done by allele specific PCR method to study the gene polymorphism in study subjects.
Study found that (+1059 G/C) genotype distribution among case and controls was found to be significant (p=0.001), Higher C allele frequency (0.16) was observed compared to controls (0.04). +1059 GC and CC had 2.72 (1.12-6.61), 20.56 (1.16-362.1) risk for T2D. It has been observed, HTN, Obesity, Smoking and alcoholism was found to be associated with increased risk of T2D, and a significant difference was observed in biochemical parameters.
Study concluded that gene polymorphism was found to be associated with risk of Type 2 Diabetes and risk was linked with heterozygosity and mutant homozygosity. Hypertension, Obesity, Smoking and alcoholism increases the risk of occurrence of Type 2 Diabetes.
C反应蛋白（CRP）是一种与2型糖尿病、肥胖、胰岛素抵抗和心血管疾病相关的炎症标志物。
本研究评估100例2型糖尿病患者和100例健康对照者中该基因CRP +1059 G/C多态性的关联。
本研究采用等位基因特异性PCR方法研究研究对象的基因多态性。
研究发现病例组和对照组之间（+1059 G/C）基因型分布存在显著差异（p = 0.001），与对照组（0.04）相比，观察到更高的C等位基因频率（0.16）。+1059 GC和CC患2型糖尿病的风险分别为2.72（1.12 - 6.61）、20.56（1.16 - 362.1）。据观察，高血压、肥胖、吸烟和酗酒与2型糖尿病风险增加相关，并且在生化参数方面观察到显著差异。
研究得出结论，该基因多态性与2型糖尿病风险相关，风险与杂合性和突变纯合性有关。高血压、肥胖、吸烟和酗酒会增加2型糖尿病的发生风险。
