School of Chinese Medicine, China Medical University, Taichung, Taiwan, R.O.C.
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, R.O.C.
In Vivo. 2019 Sep-Oct;33(5):1685-1690. doi: 10.21873/invivo.11656.
BACKGROUND/AIM: C-Reactive protein (CRP) is a common marker of inflammation. Elevated CRP levels have been associated with increased risk of development of type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association of CRP gene polymorphisms with early-onset T2DM and the effect of genetic variants on CRP level.
In total, 948 individuals with early-onset (n=271) or late-onset (n=677) T2DM were enrolled in the study. Five single-nucleotide polymorphisms (SNPs) in the CRP gene, namely rs3093077, rs2808630, rs1800947, rs11265263, and rs11265265, were selected for genotyping, and CRP levels were measured.
Genotypic, allelic, and haplotype frequencies of these five SNPs were not significantly different between patients with early- and those with late-onset. T2DM Higher serum CRP levels were independently associated with the C-allele of rs3093077 and T-allele of rs11265265 (p<0.001). Furthermore, the C-allele of rs3093077 was associated with higher CRP level in both early- (p=0.016) and late-onset (p<0.001) T2DM.
CRP gene variants may contribute to the risk of early-onset T2DM by affecting the serum CRP level.
背景/目的：C 反应蛋白（CRP）是炎症的常见标志物。CRP 水平升高与 2 型糖尿病（T2DM）的发病风险增加有关。本研究旨在评估 CRP 基因多态性与早发 T2DM 的相关性，以及遗传变异对 CRP 水平的影响。
共纳入 948 例早发（n=271）或晚发（n=677）T2DM 患者。选择 CRP 基因中的 5 个单核苷酸多态性（SNP），即 rs3093077、rs2808630、rs1800947、rs11265263 和 rs11265265 进行基因分型，并测量 CRP 水平。
这些 5 个 SNP 的基因型、等位基因和单倍型频率在早发和晚发 T2DM 患者之间无显著差异。较高的血清 CRP 水平与 rs3093077 的 C 等位基因和 rs11265265 的 T 等位基因独立相关（p<0.001）。此外，rs3093077 的 C 等位基因与早发（p=0.016）和晚发（p<0.001）T2DM 患者的 CRP 水平升高有关。
CRP 基因变异可能通过影响血清 CRP 水平，导致早发 T2DM 的发病风险增加。
