Epidemiology Program, College of Health Sciences, University of Delaware, 100 Discovery Blvd, 7th floor, Newark, DE, USA.
Department of Epidemiology, Brown University, Providence, RI, USA.
Curr Environ Health Rep. 2019 Dec;6(4):214-224. doi: 10.1007/s40572-019-00256-2.
We examined recent research on associations of prenatal and early-childhood exposure to the antimicrobial compounds, triclosan, and parabens, with the risk of asthma and eczema in children. We will discuss potential biological mechanisms of this association and highlight strengths and limitations of the study design and exposure assessment of current findings.
Results of available toxicological and epidemiologic studies indicate a potential link of triclosan and paraben exposures with asthma and eczema in children, as well as changes in microbiome diversity and immune dysfunction, which could possibly mediate an association with the health outcomes. A small number of studies suggest that triclosan and paraben exposures could be related to the risk of asthma and eczema in children. Although current findings are far from conclusive, there is emerging evidence that changes in microbiome diversity and immune function from antimicrobial exposure may mediate these relations.
我们研究了近期有关儿童产前和幼儿期接触抗菌化合物三氯生和对羟基苯甲酸酯与哮喘和湿疹风险的关联的研究。我们将讨论这种关联的潜在生物学机制，并强调当前研究结果的研究设计和暴露评估的优势和局限性。
现有毒理学和流行病学研究的结果表明，三氯生和对羟基苯甲酸酯暴露与儿童哮喘和湿疹之间存在潜在联系，以及微生物组多样性和免疫功能障碍的变化，这可能可以介导与健康结果的关联。少数研究表明，三氯生和对羟基苯甲酸酯暴露可能与儿童哮喘和湿疹的风险有关。尽管目前的研究结果还远不能得出结论，但越来越多的证据表明，抗菌剂暴露引起的微生物组多样性和免疫功能的变化可能介导这些关系。
