Huang Xiaobin, Das Ritopa, Patel Avi, Nguyen Thanh Duc
University of Connecticut.
Regen Eng Transl Med. 2018 Dec;4(4):216-237. doi: 10.1007/s40883-018-0064-0. Epub 2018 Jun 25.
A wide range of techniques and methods are actively invented by clinicians and scientists who are dedicated to the field of musculoskeletal tissue regeneration. Biological, chemical, and physiological factors, which play key roles in musculoskeletal tissue development, have been extensively explored. However, physical stimulation is increasingly showing extreme importance in the processes of osteogenic and chondrogenic differentiation, proliferation and maturation through defined dose parameters including mode, frequency, magnitude, and duration of stimuli. Studies have shown manipulation of physical microenvironment is an indispensable strategy for the repair and regeneration of bone and cartilage, and biophysical cues could profoundly promote their regeneration. In this article, we review recent literature on utilization of physical stimulation, such as mechanical forces (cyclic strain, fluid shear stress, etc.), electrical and magnetic fields, ultrasound, shock waves, substrate stimuli, etc., to promote the repair and regeneration of bone and cartilage tissue. Emphasis is placed on the mechanism of cellular response and the potential clinical usage of these stimulations for bone and cartilage regeneration.
致力于肌肉骨骼组织再生领域的临床医生和科学家们积极发明了各种各样的技术和方法。在肌肉骨骼组织发育中起关键作用的生物、化学和生理因素已得到广泛探索。然而，通过确定包括刺激模式、频率、强度和持续时间在内的剂量参数，物理刺激在成骨和软骨分化、增殖及成熟过程中日益显示出极其重要的作用。研究表明，对物理微环境的操控是骨和软骨修复与再生不可或缺的策略，生物物理信号可显著促进它们的再生。在本文中，我们综述了有关利用物理刺激（如机械力（循环应变、流体剪切应力等）、电场和磁场、超声、冲击波、基质刺激等）促进骨和软骨组织修复与再生的最新文献。重点在于细胞反应机制以及这些刺激在骨和软骨再生方面的潜在临床应用。
