Raffington Laurel, Mallard Travis, Harden K Paige
Department of Psychology, University of Texas, Austin, Texas 78712, USA.
Population Research Center, University of Texas, Austin, Texas 78712, USA.
Annu Rev Dev Psychol. 2020 Dec;2:389-411. doi: 10.1146/annurev-devpsych-051820-123945. Epub 2020 Oct 16.
Polygenic scores offer developmental psychologists new methods for integrating genetic information into research on how people change and develop across the life span. Indeed, polygenic scores have correlations with developmental outcomes that rival correlations with traditional developmental psychology variables, such as family income. Yet linking people's genetics with differences between them in socially valued developmental outcomes, such as educational attainment, has historically been used to justify acts of state-sponsored violence. In this review, we emphasize that an interdisciplinary understanding of the environmental and structural determinants of social inequality, in conjunction with a transactional developmental perspective on how people interact with their environments, is critical to interpreting associations between polygenic measures and phenotypes. While there is a risk of misuse, early applications of polygenic scores to developmental psychology have already provided novel findings that identify environmental mechanisms of life course processes that can be used to diagnose inequalities in social opportunity.
多基因分数为发展心理学家提供了新的方法,可将遗传信息整合到关于人们在整个生命周期中如何变化和发展的研究中。事实上,多基因分数与发展结果的相关性可与传统发展心理学变量(如家庭收入)的相关性相媲美。然而,将人们的遗传学与他们在社会重视的发展结果(如教育程度)方面的差异联系起来,在历史上一直被用来为国家支持的暴力行为辩护。在本综述中,我们强调,对社会不平等的环境和结构决定因素进行跨学科理解,并结合关于人们如何与环境互动的交互发展视角,对于解释多基因测量与表型之间的关联至关重要。虽然存在被滥用的风险,但多基因分数在发展心理学中的早期应用已经提供了新的发现,这些发现确定了生命历程过程的环境机制,可用于诊断社会机会的不平等。