Gong Ge, Yin Jian, Yang Xiang, Zhang Xing Hu, Zhang Yuan, Wan Wen Hui
Department of Geriatrics,Nanjing General Hospital of PLA,Nanjing 210002,China.
Department of Orthopaedics,the Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing 211100,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Dec 20;40(6):827-831. doi: 10.3881/j.issn.1000-503X.10273.
Long non-coding RNA (lncRNA) refer to transcripts longer than 200 nucleotides that have a low coding potential. Autophagy,a unique life phenomenon of eukaryotic cells,removes excess or damaged organelles during cell growth and development and plays a key role in maintaining homeostasis. As a key regulator of cellular metabolism,lncRNA are involved in disease treatment by regulating autophagy. This article summarizes the role of lncRNA in the treatment of cancer,cardiovascular and cerebrovascular diseases,neurodegenerative diseases,and bacterial infections and analyzes the molecular mechanisms of lncRNA in regulating autophagy,along with prospects of its applications in other areas.
长链非编码RNA（lncRNA）是指长度超过200个核苷酸且编码潜能较低的转录本。自噬是真核细胞独特的生命现象，在细胞生长发育过程中清除多余或受损的细胞器，对维持细胞内稳态起关键作用。lncRNA作为细胞代谢的关键调节因子，通过调控自噬参与疾病治疗。本文综述了lncRNA在癌症、心脑血管疾病、神经退行性疾病及细菌感染治疗中的作用，分析了lncRNA调控自噬的分子机制，并展望了其在其他领域的应用前景。
