表观遗传异常与 microRNAs 表达失调在癌症中的相互作用。
Interplay between epigenetic abnormalities and deregulated expression of microRNAs in cancer.
机构信息
Department of Biochemistry, Rashid Latif Medical College, Lahore, Pakistan.
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Semin Cancer Biol. 2019 Oct;58:47-55. doi: 10.1016/j.semcancer.2019.02.003. Epub 2019 Feb 8.
Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.
表观遗传异常和非编码 RNA 的异常表达是非癌细胞的两个新兴特征，它们都负责基因表达失调。在这篇综述中，我们描述了这两者之间的相互作用。具体主题包括肿瘤抑制 miRNA 的表观遗传沉默、致癌 miRNA 的表观遗传激活、miRNA 引起的表观遗传异常以及通过表观遗传机制调节 miRNA 表达的天然化合物。
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