Lin Po-Hung, Lin Shun-Ku, Hsu Ren-Jun, Pang See-Tong, Chuang Cheng-Keng, Chang Ying-Hsu, Liu Jui-Ming
Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, Taiwan.
Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
J Clin Med. 2019 Feb 8;8(2):218. doi: 10.3390/jcm8020218.
Depression is associated with higher mortality in prostate cancer. However, whether traditional Chinese medicine (TCM) for depression improves outcomes in patients with prostate cancer is unclear. This retrospective cohort study evaluated the association between TCM for depression and mortality in patients with prostate cancer. During the period 1998⁻2012, a total of 248 prostate cancer patients in Taiwan with depression were enrolled and divided into three groups: TCM for depression (n = 81, 32.7%), TCM for other purposes (n = 53, 21.3%), and no TCM (n = 114, 46.0%). During a median follow-up of 6.2 years, 12 (14.8%), 13 (24.5%), and 36 (31.6%) deaths occurred in the TCM for depression, TCM for other purposes, and no TCM groups, respectively. After adjusting age at diagnosis, urbanization, insured amount, comorbidity disease, and prostate cancer type, TCM for depression was associated with a significantly lower risk of overall mortality based on a multivariate-adjusted Cox proportional-hazards model (hazard ratio 0.42, 95% confidence interval: 0.21⁻0.85, p = 0.02) and Kaplan⁻Meier survival curve (log-rank test, p = 0.0055) compared to no TCM. In conclusion, TCM for depression may have a positive association with the survival of prostate cancer patients with depression.
抑郁症与前列腺癌患者较高的死亡率相关。然而，用于治疗抑郁症的中药是否能改善前列腺癌患者的预后尚不清楚。这项回顾性队列研究评估了用于治疗抑郁症的中药与前列腺癌患者死亡率之间的关联。在1998年至2012年期间，台湾共有248例患有抑郁症的前列腺癌患者入组，并分为三组：用于治疗抑郁症的中药组（n = 81，32.7%）、用于其他目的的中药组（n = 53，21.3%）和未使用中药组（n = 114，46.0%）。在中位随访6.2年期间，用于治疗抑郁症的中药组、用于其他目的的中药组和未使用中药组分别有12例（14.8%）、13例（24.5%）和36例（31.6%）死亡。在调整诊断时的年龄、城市化程度、保险金额、合并症疾病和前列腺癌类型后，基于多变量调整的Cox比例风险模型（风险比0.42，95%置信区间：0.21 - 0.85，p = 0.02）和Kaplan-Meier生存曲线（对数秩检验，p = 0.0055），与未使用中药相比，用于治疗抑郁症的中药与总体死亡率显著较低的风险相关。总之，用于治疗抑郁症的中药可能与患有抑郁症的前列腺癌患者的生存呈正相关。
