Laboratory for Micro-Sized Functional Materials and College of Elementary Education and Department of Chemistry, Capital Normal University, Beijing, 100048, China.
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China.
J Nanosci Nanotechnol. 2019 Jun 1;19(6):3319-3325. doi: 10.1166/jnn.2019.16119.
ZrN powders were successfully synthesized via a facile, economical and efficient gas-solid elemental combination method. The feasibility of biological applications for the ZrN powders were further studied. Firstly, the physical properties including hardness, density and surface roughness were characterized. These results indicated remarkable physical property of ZrN with the harness, density and surface roughness of 551.6 gf · mm, 6.47 g cm and 0.11 μm, respectively. Then the cytotoxicity was evaluated and the hemolysis activity was also performed in red blood cells (RBCs) of mice to investigate the biocompatibility of ZrN powders. Meanwhile, the potentiodynamic polarization test was carried out in PBS to explore its corrosion resistance. The ZrN powders with remarkable physical property and good biocompatibility were demonstrated to have potential application in the field of bone tissue engineering especially in implants protective coatings.
采用简便、经济、高效的气-固元素组合法成功合成了 ZrN 粉末。进一步研究了 ZrN 粉末在生物应用方面的可行性。首先，对其物理性能，包括硬度、密度和表面粗糙度进行了表征。结果表明，ZrN 具有显著的物理性能，硬度、密度和表面粗糙度分别为 551.6gf·mm、6.47gcm 和 0.11μm。然后评估了细胞毒性，并用小鼠的红细胞（RBC）进行了溶血活性实验，以研究 ZrN 粉末的生物相容性。同时，在 PBS 中进行了动电位极化测试，以研究其耐腐蚀性。具有显著物理性能和良好生物相容性的 ZrN 粉末在骨组织工程领域，特别是在植入物保护涂层方面具有潜在的应用。
