来自美国患者的四株携带菌的共轭转移、全基因组测序和质粒分析。
Conjugal Transfer, Whole-Genome Sequencing, and Plasmid Analysis of Four -Bearing Isolates from U.S. Patients.
机构信息
Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
出版信息
Antimicrob Agents Chemother. 2019 Mar 27;63(4). doi: 10.1128/AAC.02417-18. Print 2019 Apr.
Abstract
Four clinical isolates bearing gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to ; plasmids were stable in conjugants after multiple passages on nonselective media. was located on an IncX4 ( = 3) or IncN ( = 1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate that the -bearing plasmids in this study were highly transferable and stable in the recipients.
摘要
四个携带基因的临床分离株被鉴定。所有分离株均表现出将多粘菌素耐药性转移至的能力；质粒在非选择性培养基上多次传代后在接合子中稳定。位于 IncX4（=3）或 IncN（=1）质粒上。IncN 质粒还携带 13 个额外的抗生素耐药基因。结果表明，本研究中携带的质粒具有高度的可转移性和在受体中的稳定性。
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