Laboratory of Medical Microbiology, Wilrijk, Belgium.
Euro Surveill. 2016 Jul 7;21(27). doi: 10.2807/1560-7917.ES.2016.21.27.30280.
We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.
我们在猪和牛源耐多粘菌素大肠杆菌中发现了一种新型质粒介导的多粘菌素耐药基因，该基因不含有 mcr-1。该基因被命名为 mcr-2，是一种位于 IncX4 质粒上的 1617 个碱基对的磷酸乙醇胺转移酶，与 mcr-1 的核苷酸序列相似度为 76.7%。在比利时的猪源耐多粘菌素大肠杆菌（53 株中的 11 株）中 mcr-2 的检出率高于 mcr-1（53 株中的 7 株）。这些数据表明，在对耐多粘菌素革兰氏阴性病原体的分子流行病学监测中，应立即引入 mcr-2 的筛查。
