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[一例由非甾体抗炎药贴剂引起的小肠溃疡病例]

[A case of small intestinal ulcer caused by non-steroidal anti-inflammatory drugs patch].

作者信息

Aoyama Yuki, Takahashi Sakuma, Inaba Tomoki, Izumikawa Koichi, Nakamura Satoko

机构信息

Department of Gastroenterology, Kagawa Prefectural Central Hospital.

Department of Pathology, Kagawa Prefectural Central Hospital.

出版信息

Nihon Shokakibyo Gakkai Zasshi. 2019;116(2):145-152. doi: 10.11405/nisshoshi.116.145.

Abstract

A ring-shaped ulcer was observed in the ileum of a 70-year-old male patient with capsule endoscopy of the small intestine performed for detailed investigation of black stools and iron deficiency anemia. Non-steroidal anti-inflammatory drugs (NSAIDs) use in patch form was considered as the etiology. The NSAIDs patches were discontinued, and protective therapy for small intestinal mucosa was initiated. The anemia improved;however, ileus originating from the site of the ulcer required surgical resection. The resected specimen showed no specific pathological findings. Based on the clinical findings, the patient was diagnosed with NSAIDs-induced small intestinal ulcer. The use of NSAIDs patches should be considered as a potential cause of injury to gastrointestinal mucosa.

摘要

对一名70岁男性患者进行小肠胶囊内镜检查,以详细调查黑便和缺铁性贫血,结果在其回肠发现一个环形溃疡。病因被认为是使用了贴片形式的非甾体抗炎药(NSAIDs)。停用了NSAIDs贴片,并开始对小肠黏膜进行保护性治疗。贫血症状有所改善;然而,源自溃疡部位的肠梗阻需要手术切除。切除的标本未显示出特定的病理结果。根据临床表现,该患者被诊断为NSAIDs诱导的小肠溃疡。应考虑使用NSAIDs贴片可能是胃肠道黏膜损伤的一个原因。

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