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Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.单纯病灶内曲安奈德注射或联合肉毒毒素 A 注射治疗增生性瘢痕无效：一项双盲对照的初步研究。
Dermatol Ther. 2019 Mar;32(2):e12781. doi: 10.1111/dth.12781. Epub 2019 Jan 29.
2
Photodynamic therapy for a hypertrophic scarring: a promising choice.光动力疗法治疗增生性瘢痕：一种有前途的选择。
Photodermatol Photoimmunol Photomed. 2011 Dec;27(6):334-5. doi: 10.1111/j.1600-0781.2011.00619.x.
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Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars.皮损内注射曲安奈德单独或联合5-氟尿嘧啶治疗瘢痕疙瘩和增生性瘢痕。
Clin Exp Dermatol. 2009 Mar;34(2):219-23. doi: 10.1111/j.1365-2230.2007.02631.x. Epub 2008 Nov 6.
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Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration.信号转导与转录激活因子3（Stat3）通过促进胶原蛋白生成、细胞增殖和迁移，在瘢痕疙瘩发病机制中发挥作用。
Oncogene. 2006 Aug 31;25(39):5416-25. doi: 10.1038/sj.onc.1209531. Epub 2006 Apr 17.
5
Pruritus, pain, and small nerve fiber function in keloids: a controlled study.瘢痕疙瘩中的瘙痒、疼痛及小神经纤维功能：一项对照研究。
J Am Acad Dermatol. 2004 Dec;51(6):1002-6. doi: 10.1016/j.jaad.2004.07.054.
6
Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments.瘢痕疙瘩性和增生性胸骨切开术瘢痕的治疗反应：病灶内注射皮质类固醇、5-氟尿嘧啶和585纳米闪光灯泵浦脉冲染料激光治疗的比较。
Arch Dermatol. 2002 Sep;138(9):1149-55. doi: 10.1001/archderm.138.9.1149.
7
[Mechanism of abnormal scars with treatment of steroid].
Zhonghua Wai Ke Za Zhi. 2000 May;38(5):378-81.

曲安奈德皮损内注射成功治疗瘢痕疙瘩患者

Successful Treatment of Intralesional Triamcilonon Acetonide Injection in Keloid Patients.

作者信息

Huu Nghi Dinh, Huu Sau Nguyen, Thi Xuan Le, Van Thuong Nguyen, Minh Phuong Pham Thi, Minh Trang Trinh, Van Tam Hoang, Cam Van Tran, Huyen My Le, Hau Khang Tran, Gandolfi Marco, Satolli Francesca, Feliciani Claudio, Tirant Michael, Vojvodic Aleksandra, Lotti Torello

机构信息

National Hospital of Dermatology and Venereology, Hanoi, Vietnam.

Hanoi Medical University, Hanoi, Vietnam.

出版信息

Open Access Maced J Med Sci. 2019 Jan 28;7(2):275-278. doi: 10.3889/oamjms.2019.093. eCollection 2019 Jan 30.

DOI:10.3889/oamjms.2019.093
PMID:30745979
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6364710/
Abstract

AIM

Evaluation the effect of intralesional corticosteroid injection on keloid, at the National Hospital of Dermatology and Venereology from 1/2009 to 12/2009.

METHODS

A group of 65 patients with keloid were randomly assigned into three groups. In the studied group, 33 patients were intralesionally injected 7.5 mg/1 cm of TCA. In the control group, TAC 32 patients were intralesionally injected 15 mg/1 cm of TCA. The result was evaluated basing on the criteria of Henderson (1998) and El-Tonsy (1996).

RESULTS

In comparison between 2 groups, good to excellent improvement in the studied group was statistically higher than the control group (90.7% versus 68.7%; p < 0.05). After each injection, the thickness of the scar was reduced 1.24 ± 0.53 mm in the studied group and 0.81 ± 0.39 mm in the control group. The disappearance of pain and itching after treatment were 86.6% and 95.5% in the studied group and 78.1% and 80% in the control group (p > 0.05). Ulceration, acne and troublesome with menstrual cycles were sometimes were noted more frequently in the control group than in the studied group.

CONCLUSION

Intralesional triamcinolone acetonide injection had a good result, and 7.5 mg/1 cm scar is the best dose for treatment of keloid.

摘要

目的

评估2009年1月至2009年12月期间，在国家皮肤性病医院进行的皮损内注射皮质类固醇对瘢痕疙瘩的治疗效果。

方法

将65例瘢痕疙瘩患者随机分为三组。研究组33例患者皮损内注射7.5 mg/1 cm的曲安西龙。对照组32例患者皮损内注射15 mg/1 cm的曲安西龙。根据亨德森（1998年）和埃尔-通西（1996年）的标准对结果进行评估。

结果

两组比较，研究组的良好至极佳改善率在统计学上高于对照组（90.7%对68.7%；p<0.05）。每次注射后，研究组瘢痕厚度减少1.24±0.53 mm，对照组减少0.81±0.39 mm。治疗后研究组疼痛和瘙痒消失率分别为86.6%和95.5%，对照组分别为78.1%和80%（p>0.05）。对照组溃疡、痤疮和月经周期问题的出现频率有时高于研究组。

结论

皮损内注射曲安奈德效果良好，7.5 mg/1 cm瘢痕是治疗瘢痕疙瘩的最佳剂量。