Ji Ting, Han Yuehu, Yang Wenwen, Xu Baoping, Sun Meng, Jiang Shuai, Yu Yuan, Jin Zhenxiao, Ma Zhiqiang, Yang Yang, Hu Wei
Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi'an, China.
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an, China.
J Cell Physiol. 2019 Sep;234(9):14773-14782. doi: 10.1002/jcp.28275. Epub 2019 Feb 11.
When endoplasmic reticulum (ER) homeostasis is disrupted, known as ER stress (ERS), the ER generates an adaptive signaling pathway called the unfolded protein response to maintain the homeostasis of this organelle. However, if homeostasis is not restored, the ER initiates death signaling pathways, which contribute to the pathogenesis of various disorders. The activation of inflammatory mechanisms is also emerging as a crucial component of cardiovascular and metabolic disorders. Furthermore, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome has attracted more attention than others and is the best-characterized member of the NLR family of inflammasomes to date. ERS intersects with many different inflammatory pathways, particularly the NLRP3 inflammasome. In this review, we focus on the interactions between ERS and the NLRP3 inflammasome. The pharmacologic and nonpharmaceutical manipulation of these two processes may offer novel opportunities for the treatment of cardiovascular and metabolic disorders.
当内质网（ER）稳态被破坏，即所谓的内质网应激（ERS）时，内质网会产生一种适应性信号通路，称为未折叠蛋白反应，以维持该细胞器的稳态。然而，如果稳态未能恢复，内质网会启动死亡信号通路，这会导致各种疾病的发病机制。炎症机制的激活也正在成为心血管和代谢紊乱的一个关键组成部分。此外，含pyrin结构域的核苷酸结合寡聚化结构域样受体家族3（NLRP3）炎性小体比其他炎性小体更受关注，是迄今为止NLR炎性小体家族中特征最明确的成员。内质网应激与许多不同的炎症途径相互交叉，尤其是NLRP3炎性小体。在这篇综述中，我们重点关注内质网应激与NLRP3炎性小体之间的相互作用。对这两个过程的药物和非药物调控可能为心血管和代谢紊乱的治疗提供新的机会。
