人类血液淋巴细胞亚群的年龄依赖性变化。
Age-dependent changes of human blood lymphocyte subpopulations.
作者信息
Clot J, Charmasson E, Brochier J
出版信息
Clin Exp Immunol. 1978 May;32(2):346-51.
T- and B-lymphocyte populations were enumerated at four stages of life: at the newly born, infant, adult and aged stages. The proportion of T cells detected by E rosettes and an anti-human T-lymphocyte antigen (HTLA) serum incresed from new-born children to adults, then decreased with ageing. The antiserum detected less mature T cells in aged people. The percentages of cell forming 'active' E rosettes increased with ageing. Lower numbers of B cells bearing surface immunoglobulins were found in adults.Complement receptor-bearing lymphocytes (percentages and absolute numbers) decreased from new-born children to aged humans. Finally, the number of monocytes were significantly greater in the young than in adult and aged people. Such results bring new data concerning the age-dependent changes of lymphocyte subpopulations and concerning the significance of various techniques used together to detect mononuclear cell populations in the human peripheral blood.
在生命的四个阶段对T淋巴细胞和B淋巴细胞群体进行了计数：新生儿期、婴儿期、成年期和老年期。通过E花环和抗人T淋巴细胞抗原（HTLA）血清检测到的T细胞比例从新生儿到成年人逐渐增加，然后随着年龄增长而下降。该抗血清在老年人中检测到的成熟T细胞较少。形成“活性”E花环的细胞百分比随年龄增长而增加。在成年人中发现携带表面免疫球蛋白的B细胞数量较少。携带补体受体的淋巴细胞（百分比和绝对数量）从新生儿到老年人逐渐减少。最后，年轻人中的单核细胞数量明显多于成年人和老年人。这些结果带来了有关淋巴细胞亚群随年龄变化的新数据，以及有关共同使用各种技术检测人外周血单核细胞群体的意义的新数据。
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