年轻和年长受试者外周血淋巴细胞的植物促细胞分裂剂反应
Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.
作者信息
Foad B S, Adams L E, Yamauchi Y, Litwin A
出版信息
Clin Exp Immunol. 1974 Aug;17(4):657-64.
Abstract
Quantitation of the response of peripheral blood lymphocytes to the phytomitogens phytohaemagglutinin-M, concanavalin A, and pokeweed mitogen was compared in thirteen young subjects and thirteen older subjects. Both dose of phytomitogen and duration of lymphocyte culture were evaluated. Younger individuals had higher responses to all three phytomitogens after 3 days of culture, whereas older individuals had higher responses after 5 days of culture. The concentration of phytomitogens required to produce maximal stimulation in both groups varied with culture duration.
摘要
在13名年轻受试者和13名年长受试者中比较了外周血淋巴细胞对植物血凝素-M、刀豆球蛋白A和商陆有丝分裂原等植物有丝分裂原的反应定量。对植物有丝分裂原的剂量和淋巴细胞培养持续时间均进行了评估。培养3天后，较年轻个体对所有三种植物有丝分裂原的反应更高，而培养5天后，年长个体的反应更高。两组中产生最大刺激所需的植物有丝分裂原浓度随培养持续时间而变化。
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