Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.
作者信息
Foad B S, Adams L E, Yamauchi Y, Litwin A
出版信息
Clin Exp Immunol. 1974 Aug;17(4):657-64.
Abstract
Quantitation of the response of peripheral blood lymphocytes to the phytomitogens phytohaemagglutinin-M, concanavalin A, and pokeweed mitogen was compared in thirteen young subjects and thirteen older subjects. Both dose of phytomitogen and duration of lymphocyte culture were evaluated. Younger individuals had higher responses to all three phytomitogens after 3 days of culture, whereas older individuals had higher responses after 5 days of culture. The concentration of phytomitogens required to produce maximal stimulation in both groups varied with culture duration.
摘要
相似文献
1
Phytomitogen responses of peripheral blood lymphocytes in young and older subjects.
Clin Exp Immunol. 1974 Aug;17(4):657-64.
2
Effect of concanavalin A on human lymphoid cell lines and normal peripheral lymphocytes.
J Natl Cancer Inst. 1972 Oct;49(4):935-41.
3
Activation of B lymphocytes by concanavalin A in the presence of humoral factors released by T cells.
Transplant Proc. 1972 Sep;4(3):321-4.
4
Inhibition of lymphocyte triggering by cytochalasin B.
Transplant Proc. 1972 Sep;4(3):325-7.
5
Lymphocyte transformation induced by autologous cells: stimulation by cultured lymphoblast lines.
J Clin Invest. 1972 Dec;51(12):3124-32. doi: 10.1172/JCI107139.
6
[Age and the relationship between the concentration of phytohemagglutinin and lymphocyte blast-transformation in tissue culture].
Tsitol Genet. 1976 May-Jun;10(3):195-7.
7
[3H-thymidine-paper disc-counting of in vitro lymphocyte transformation demonstrated on phytomitogen-activated rabbit peripheral blood lymphocytes (author's transl)].
Allerg Immunol (Leipz). 1981;27(2):102-23.
8
Phytomitogen- and antigen-induced blast transformation of feline lymphocytes.
Am J Vet Res. 1975 Oct;36(10):1489-94.
9
The in vitro effect of concanavalin A on human lymphocytes: blastic transformation, DNA synthesis, DNA content and dry mass.
Folia Biol (Praha). 1973;19(3):161-8.
10
引用本文的文献
1
Immune responses of Iranian patients with visceral leishmaniasis and recovered individuals to LCR1 of Leishmania infantum.
Clin Vaccine Immunol. 2014 Apr;21(4):518-25. doi: 10.1128/CVI.00711-13. Epub 2014 Feb 5.
2
Skin tumors in aging Long Evans rats.
J Natl Med Assoc. 2002 Jun;94(6):506-10.
3
Reduced lymphocyte colony formation with age.
Clin Exp Immunol. 1982 Jul;49(1):129-34.
4
Human B cell function in normal individuals of various ages. 1. In vitro enumeration of pokeweed-induced peripheral blood lymphocyte immunoglobulin-synthesizing cells and the comparison of the results with numbers of peripheral B and T cells, mitogen responses, and levels of serum immunoglobulins.
Clin Exp Immunol. 1981 Jun;44(3):646-53.
5
Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.
Clin Exp Immunol. 1982 Apr;48(1):148-54.
6
Immunoresponsiveness in ulcerative colitis and Crohn's disease--effect of colectomy and suppression of disease activity.
West J Med. 1988 Apr;148(4):421-5.
7
Peripheral blood lymphocyte response to phytomitogens in systemic lupus erythematosus.
Ann Rheum Dis. 1975 Oct;35(5):407-14. doi: 10.1136/ard.35.5.407.
8
Lymphocyte responses to phytohaemagglutinin: age-related effects.
Immunology. 1976 Oct;31(4):583-7.
9
[Age dependence of immunological methods for detecting an immunodeficiency state (author's transl)].
Klin Wochenschr. 1978 Aug 15;56(16):825-33. doi: 10.1007/BF01489717.
10
Cytokinetic analysis of the impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin.
J Exp Med. 1979 May 1;149(5):1029-41. doi: 10.1084/jem.149.5.1029.
本文引用的文献
1
IMMUNOLOGICAL DEFECT IN AGED POPULATION AND ITS RELATIONSHIP TO CANCER.
Cancer. 1965 Feb;18:201-4. doi: 10.1002/1097-0142(196502)18:2<201::aid-cncr2820180211>3.0.co;2-v.
2
Mitogenic effect of phytohaemagglutinin at different ages.
Nature. 1967 Jul 8;215(5097):193-4. doi: 10.1038/215193a0.
3
The establishment of a normal human population dose-response curve for lymphocytes cultured with PHA (phytohaemagglutinin).
Clin Exp Immunol. 1971 Mar;8(3):421-5.
4
Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.
Int Arch Allergy Appl Immunol. 1970;37(5):506-31. doi: 10.1159/000230240.
5
Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases.
Clin Exp Immunol. 1971 Oct;9(4):467-76.
6
Factors influencing the stimulation of human lymphocytes by antigen during culture in vitro. Conditions for lymphocyte stimulation.
Int Arch Allergy Appl Immunol. 1972;42(6):836-51. doi: 10.1159/000230662.
7
A satisfactory quantitative test of lymphocyte response to phytohaemagglutinin for the definition of normal control values and recognition of immunological defects.
J Clin Pathol. 1972 Feb;25(2):163-8. doi: 10.1136/jcp.25.2.163.
8
Defective lymphocyte transformation and delayed hypersensitivity in Wiskott-Aldrich syndrome.
J Immunol. 1970 Apr;104(4):835-44.
9
Human lymphocyte response to phytomitogens in vitro: normal, agammaglobulinemic and paraproteinemic individuals.
J Immunol. 1969 Dec;103(6):1185-95.
Zotero 插件