COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Department of Pediatrics, Slagelse Hospital, Slagelse, Denmark.
Acta Paediatr. 2019 Sep;108(9):1632-1641. doi: 10.1111/apa.14753. Epub 2019 Mar 21.
The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.
We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC ) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birthweights <2500 g, resulting in 650 children analysed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.
Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema and number of sick days (p > 0.05 in all tests). Early age at milestone achievement was associated with male sex (p = 0.05), lower maternal age (p = 0.02), higher gestational age (p < 0.001) and paternity leave (p = 0.01). A higher 1-year language score was associated with female sex (p = 0.02) and maternal smoking during pregnancy (p = 0.01) and a higher 2-year language score with female sex (p < 0.001) and being first born (p = 0.01). A higher cognitive score was associated with female sex (p = 0.02).
Neurodevelopmental scores were unrelated to breastfeeding, persistent wheeze, eczema and number of sick days. Neurodevelopment in early childhood was mostly associated with gender.
本研究旨在确定可能影响幼儿神经发育的产前和产后因素。
我们使用了来自哥本哈根儿童哮喘前瞻性研究 2010 年（COPSAC）母婴队列的数据，但排除了有神经学诊断、胎龄<37 周和出生体重<2500 克的儿童，最终分析了 650 名儿童。神经发育评估为早期里程碑的达成年龄、1 岁和 2 岁时的语言评分以及 2 岁半时的认知评分。
神经发育评分与母乳喂养、持续性喘息、湿疹和病假天数无关（所有测试中 p>0.05）。早期里程碑的达成年龄与性别（p=0.05）、母亲年龄较小（p=0.02）、较高的胎龄（p<0.001）和陪产假（p=0.01）有关。1 岁时的语言评分较高与性别（p=0.02）和母亲在怀孕期间吸烟（p=0.01）有关，而 2 岁时的语言评分较高与性别（p<0.001）和第一胎有关（p=0.01）。认知评分较高与性别有关（p=0.02）。
神经发育评分与母乳喂养、持续性喘息、湿疹和病假天数无关。幼儿期的神经发育主要与性别有关。
