Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan 8174673441, Iran.
Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan 8174673441, Iran, e-mail:
Rev Neurosci. 2019 Jul 26;30(5):555-572. doi: 10.1515/revneuro-2018-0080.
Quercetin is a polyphenolic flavonoid, which is frequently found in fruits and vegetables. The antioxidant potential of quercetin has been studied from subcellular compartments, that is, mitochondria to tissue levels in the brain. The neurodegeneration process initiates alongside aging of the neurons. It appears in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and others, which leads to Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and other diseases. So far, no specific treatment has been identified for these diseases. Despite common treatments that help to prevent the development of disease, the condition of patients with progressive neurodegenerative diseases usually do not completely improve. Currently, the use of flavonoids, especially quercetin for the treatment of neurodegenerative diseases, has been expanded in animal models. It has also been used to treat animal models of neurodegenerative diseases. In addition, improvements in behavioral levels, as well as in cellular and molecular levels, decreased activity of antioxidant and apoptotic proteins, and increased levels of antiapoptotic proteins have been observed. Low bioavailability of quercetin has also led researchers to construct various quercetin-involved nanoparticles. The treatment of animal models of neurodegeneration using quercetin-involved nanoparticles has shown that improvements are observed in shorter periods and with use of lower concentrations. Indeed, intranasal administration of quercetin-involved nanoparticles, constructing superparamagnetic nanoparticles, and combinational treatment using nanoparticles such as quercetin and other drugs are suggested for future studies.
槲皮素是一种多酚类黄酮，经常在水果和蔬菜中发现。槲皮素的抗氧化潜力已经从亚细胞区室，即线粒体到大脑组织水平进行了研究。神经退行性过程与神经元老化同时开始。它以 Aβ 斑块、神经原纤维缠结、路易体、Pick 体等不同形式出现在大脑的不同部位，导致阿尔茨海默病、帕金森病、亨廷顿病、肌萎缩侧索硬化症和其他疾病。到目前为止，还没有针对这些疾病的特定治疗方法。尽管有一些常见的治疗方法可以帮助预防疾病的发展，但患有进行性神经退行性疾病的患者的病情通常不会完全改善。目前，黄酮类化合物，特别是槲皮素，已被用于治疗神经退行性疾病的动物模型中。它也被用于治疗神经退行性疾病的动物模型。此外，观察到行为水平、细胞和分子水平的改善，抗氧化和凋亡蛋白的活性降低，以及抗凋亡蛋白水平的升高。槲皮素的生物利用度低也促使研究人员构建了各种涉及槲皮素的纳米粒子。使用涉及槲皮素的纳米粒子治疗神经退行性疾病的动物模型表明，在较短的时间内并使用较低的浓度观察到改善。事实上，鼻内给予涉及槲皮素的纳米粒子、构建超顺磁性纳米粒子以及使用涉及纳米粒子如槲皮素和其他药物的联合治疗，都被建议用于未来的研究。
