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槲皮素纳米颗粒作为一种治疗方法：药理作用及在治疗中的潜在应用。

Quercetin nanoparticles as a therapeutic approach: pharmacological actions and potential applications in therapy.

作者信息

Baiomy Reham Farouk El-Sayed

机构信息

Zoology Department, Faculty of Science, Zagazig University, Sharkia, Egypt.

出版信息

BioTechnologia (Pozn). 2024 Dec 19;105(4):377-393. doi: 10.5114/bta.2024.145258. eCollection 2024.

DOI:10.5114/bta.2024.145258
PMID:39844873
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11748223/
Abstract

The utilization of quercetin nanoparticles as a novel therapeutic strategy has garnered significant attention in recent years. These nanoparticles offer a unique approach to enhancing delivery and effectiveness while overcoming the drawbacks of quercetin. By exploiting the advantages of nanotechnology, such as increased stability and improved bioavailability, quercetin nanoparticles hold significant potential for developing innovative treatments across various medical fields. Quercetin nanoparticles have emerged as an indispensable component in numerous pharmaceutical and medicinal formulations. They are recognized for their anticancer, antitumor, anti-inflammatory, and antidiabetic properties, making them valuable in addressing allergic reactions, metabolic disorders, inflammatory disorders, cardiovascular diseases, and arthritis. From a pharmacological perspective, quercetin nanoparticles have demonstrated beneficial effects against Alzheimer's disease, primarily through their inhibitory impact on acetylcholinesterase. Furthermore, these nanoparticles have been scientifically documented to possess antioxidant, anticarcinogenic, hepatoprotective, and cytotoxic activities. This comprehensive review aims to explore the pharmacokinetics and biological activities associated with quercetin nanoparticles. It also highlights their potential as therapeutic agents in treating a wide range of diseases, including Alzheimer's disease, cancer, and neurodegenerative disorders.

摘要

近年来，槲皮素纳米颗粒作为一种新型治疗策略的应用已引起广泛关注。这些纳米颗粒提供了一种独特的方法来提高递送效率和有效性，同时克服了槲皮素的缺点。通过利用纳米技术的优势，如提高稳定性和改善生物利用度，槲皮素纳米颗粒在各个医学领域开发创新治疗方法方面具有巨大潜力。槲皮素纳米颗粒已成为众多药物和药用制剂中不可或缺的成分。它们因其抗癌、抗肿瘤、抗炎和抗糖尿病特性而受到认可，在解决过敏反应、代谢紊乱、炎症性疾病、心血管疾病和关节炎方面具有重要价值。从药理学角度来看，槲皮素纳米颗粒已显示出对阿尔茨海默病的有益作用，主要是通过其对乙酰胆碱酯酶的抑制作用。此外，这些纳米颗粒已被科学证明具有抗氧化、抗癌、保肝和细胞毒性活性。这篇综述旨在探讨与槲皮素纳米颗粒相关的药代动力学和生物学活性。它还强调了它们作为治疗多种疾病（包括阿尔茨海默病、癌症和神经退行性疾病）的治疗剂的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/d59408f83f84/BTA-105-4-55197-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/d2acc9308aaf/BTA-105-4-55197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/710cf778d01a/BTA-105-4-55197-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/7140f8cea7bd/BTA-105-4-55197-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/7a3775d05f5a/BTA-105-4-55197-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/e8054ed6f120/BTA-105-4-55197-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/44ed7ae05b50/BTA-105-4-55197-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/ac1579b8acd7/BTA-105-4-55197-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/d59408f83f84/BTA-105-4-55197-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/d2acc9308aaf/BTA-105-4-55197-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/710cf778d01a/BTA-105-4-55197-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/7140f8cea7bd/BTA-105-4-55197-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/7a3775d05f5a/BTA-105-4-55197-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/e8054ed6f120/BTA-105-4-55197-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/44ed7ae05b50/BTA-105-4-55197-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/ac1579b8acd7/BTA-105-4-55197-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df43/11748223/d59408f83f84/BTA-105-4-55197-g008.jpg

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The neuroprotective effect of quercetin nanoparticles in the therapy of neuronal damage stimulated by acrolein.
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