College of Medicine, Department of Biomedical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Univ Angers, Université de Nantes, Inserm, CRCINA, SFR ICAT, F-49800 Angers, France.
Nutrients. 2021 Apr 16;13(4):1318. doi: 10.3390/nu13041318.
Chronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant production of pro-inflammatory cytokines leading to an increasing neuronal cell death. The decreased neuroinflammation could be obtained by using natural compounds, including flavonoids known to modulate the inflammatory responses. Among flavonoids, quercetin possess multiple pharmacological applications including anti-inflammatory, antitumoral, antiapoptotic and anti-thrombotic activities, widely demonstrated in both in vitro and in vivo studies. In this review, we describe the recent findings about the neuroprotective action of quercetin by acting with different mechanisms on the microglial cells of CNS. The ability of quercetin to influence microRNA expression represents an interesting skill in the regulation of inflammation, differentiation, proliferation, apoptosis and immune responses. Moreover, in order to enhance quercetin bioavailability and capacity to target the brain, we discuss an innovative drug delivery system. In summary, this review highlighted an important application of quercetin in the modulation of neuroinflammation and prevention of neurological disorders.
慢性神经炎症是许多中枢神经系统（CNS）疾病的病理状况，如帕金森病、阿尔茨海默病、多发性硬化症、肌萎缩侧索硬化症等。神经炎症的特征是小胶质细胞激活和伴随产生促炎细胞因子，导致神经元细胞死亡增加。通过使用天然化合物，包括已知调节炎症反应的类黄酮，可以减少神经炎症。在类黄酮中，槲皮素具有多种药理作用，包括抗炎、抗肿瘤、抗凋亡和抗血栓形成作用，在体外和体内研究中均得到广泛证实。在这篇综述中，我们描述了槲皮素通过作用于中枢神经系统的小胶质细胞的不同机制发挥神经保护作用的最新发现。槲皮素影响 microRNA 表达的能力代表了一种在调节炎症、分化、增殖、凋亡和免疫反应方面的有趣技能。此外，为了提高槲皮素的生物利用度和靶向大脑的能力，我们讨论了一种创新的药物传递系统。总之，这篇综述强调了槲皮素在调节神经炎症和预防神经疾病方面的重要应用。
