Tan Hui-Li, Teow Sin-Yeang, Pushpamalar Janarthanan
School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, 47500 Selangor Darul Ehsan, Malaysia.
Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.
Bioengineering (Basel). 2019 Feb 11;6(1):17. doi: 10.3390/bioengineering6010017.
Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP⁻hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP⁻hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed.
器官移植面临的挑战，如器官需求高和生物相容性问题，促使组织工程和再生医学领域的科学家致力于使用支架作为移植的替代方案。在不同类型的支架中，聚合物水凝胶支架因其生物相容性和与天然组织的结构相似性而受到了广泛关注。然而，水凝胶支架存在一些局限性，如机械性能较弱和缺乏生物活性。另一方面，贵金属颗粒，特别是金（Au）和银（Ag）纳米颗粒（NPs），可以掺入水凝胶基质中，形成具有增强物理和生物学特性的NP⁻水凝胶复合支架。本综述旨在突出这些复合材料在组织工程应用中的潜力。此外，还讨论了用于合成NP⁻水凝胶复合材料的主要方法以及与这些材料应用相关的可能局限性和挑战。
