Aldhaher Abdullah, Shahabipour Fahimeh, Shaito Abdullah, Al-Assaf Saphwan, Elnour Ahmed A M, Sallam El Bashier, Teimourtash Shahin, Elfadil Abdelgadir A
Department of Chemistry, Faculty of Chemistry, Sharif University of Technology, Tehran, Iran.
Orthopedic Research Center, Mashhad University of Medical Science, Mashhad, Iran.
Heliyon. 2023 Jul 5;9(7):e17050. doi: 10.1016/j.heliyon.2023.e17050. eCollection 2023 Jul.
Repairing significant bone defects remains a critical challenge, raising the clinical demand to design novel bone biomaterials that incorporate osteogenic and angiogenic properties to support the regeneration of vascularized bone. Bioactive glass scaffolds can stimulate angiogenesis and osteogenesis. In addition, natural or synthetic polymers exhibit structural similarity with extracellular matrix (ECM) components and have superior biocompatibility and biodegradability. Thus, there is a need to prepare composite scaffolds of hydrogels for vascularized bone, which incorporate to improve the mechanical properties and bioactivity of natural polymers. In addition, those composites' 3-dimensional (3D) form offer regenerative benefits such as direct doping of the scaffold with ions. This review presents a comprehensive discussion of composite scaffolds incorporated with BaG, focusing on their effects on osteo-inductivity and angiogenic properties. Moreover, the adaptation of the ion-doped hydrogel composite scaffold into a 3D scaffold for the generation of vascularized bone tissue is exposed. Finally, we highlight the challenges and future of manufacturing such biomaterials.
修复严重的骨缺损仍然是一项严峻的挑战，这增加了临床对设计新型骨生物材料的需求，这些材料应兼具成骨和血管生成特性，以支持血管化骨的再生。生物活性玻璃支架可以刺激血管生成和骨生成。此外，天然或合成聚合物与细胞外基质（ECM）成分具有结构相似性，并且具有优异的生物相容性和生物降解性。因此，有必要制备用于血管化骨的水凝胶复合支架，其结合以改善天然聚合物的机械性能和生物活性。此外，这些复合材料的三维（3D）形式提供了诸如直接用离子掺杂支架等再生益处。本综述全面讨论了含BaG的复合支架，重点关注它们对骨诱导性和血管生成特性的影响。此外，还介绍了将离子掺杂水凝胶复合支架适配成用于生成血管化骨组织的3D支架。最后，我们强调了制造此类生物材料的挑战和未来发展方向。
