Pascal Mathilde M V, Themistocleous Andreas C, Baron Ralf, Binder Andreas, Bouhassira Didier, Crombez Geert, Finnerup Nanna B, Gierthmühlen Janne, Granovsky Yelena, Groop Leif, Hebert Harry L, Jensen Troels S, Johnsen Kristinn, McCarthy Mark I, Meng Weihua, Palmer Colin N A, Rice Andrew S C, Serra Jordi, Solà Romà, Yarnitsky David, Smith Blair H, Attal Nadine, Bennett David L H
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Division of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein, Kiel, 24105, Germany.
Wellcome Open Res. 2019 Feb 1;3:63. doi: 10.12688/wellcomeopenres.14576.2. eCollection 2018.
Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors. Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography. All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through the DOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations. Large cohorts covering many possible triggers for neuropathic painMulti-disciplinary approach to study the interaction of clinical, psychosocial and genetic risk factorsHigh comparability of the data across centres thanks to harmonised protocolsOne limitation is that the length of the questionnaires might reduce the response rate and quality of responses of participants.
神经性疼痛是一种日益普遍的病症，对健康和生活质量有重大影响。然而，人们对神经性疼痛发生和维持的风险因素了解甚少。临床、遗传和社会心理因素都与慢性疼痛有关，但尚未在大型队列研究中对它们之间的相互作用进行研究。DOLORisk研究旨在探究这些因素。多中心横断面和纵向队列研究涵盖了导致神经性疼痛的主要原因（如糖尿病、手术、化疗、外伤）以及罕见病症，遵循统一方案对参与者进行表型分析。该核心方案将参与者在一组问卷上给出的答案与其基因分析结果相关联。少数参与者会接受更深入的表型分析程序，包括神经学检查、神经传导研究、阈值跟踪、定量感觉测试、条件性疼痛调制和脑电图检查。所有研究均已按照国家法律要求获得其所在地区伦理委员会的批准。研究结果通过DOLORisk网站、科学会议、开放获取出版物以及与患者组织合作进行传播。涵盖多种可能引发神经性疼痛因素的大型队列研究采用多学科方法研究临床、社会心理和遗传风险因素之间的相互作用由于方案统一，各中心数据具有高度可比性一个局限性是问卷的长度可能会降低参与者的回复率和回复质量。
