在中国人群中，循环 miR-29b 与非酒精性脂肪性肝病呈正相关。
Circulating miR-29b positively correlates with non-alcoholic fatty liver disease in a Chinese population.
机构信息
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of General Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
J Dig Dis. 2019 Apr;20(4):189-195. doi: 10.1111/1751-2980.12716. Epub 2019 Apr 3.
OBJECTIVE
Early screening of non-alcoholic fatty liver disease (NAFLD) is of great significance for the early detection and intervention in NAFLD. MicroRNAs (miRNAs) are important regulators of metabolic diseases including NAFLD. The aim of this study was to investigate the association of serum miR-29a-c with NAFLD in a Chinese population.
METHODS
Participants were divided into four groups based on the presence or absence of NAFLD and/or type 2 diabetes mellitus (T2DM). Quantitative polymerase chain reaction analysis was performed to quantify serum level of miR-29a-c. The association of miR-29a-c with NAFLD was evaluated.
RESULTS
Serum miR-29b, but not miR-29a or miR-29c, was positively associated with NAFLD (odds ratio [OR] 2.04 [1.16- 3.58], P = 0.013). Additionally, age, serum triglyceride and fasting plasma glucose (FPG) levels were independently associated with miR-29b (β ± standard error [SE] = 0.004 ± 0.002, P = 0.019 for age; β ± SE = 0.110 ± 0.054, P = 0.042 for triglyceride; and β ± SE = 0.389 ± 0.161, P = 0.016 for FPG). MiR-29b level was positively correlated with intrahepatic lipid content (β ± SE = 6.055 ± 2.630, P = 0.024) after adjusted for age, sex, and body mass index.
CONCLUSIONS
Serum miR-29b was associated with intrahepatic lipid content and NAFLD in a Chinese population-based study.
目的
非酒精性脂肪性肝病（NAFLD）的早期筛查对于 NAFLD 的早期发现和干预具有重要意义。微小 RNA（miRNA）是包括 NAFLD 在内的代谢性疾病的重要调节因子。本研究旨在探讨中国人群血清 miR-29a-c 与 NAFLD 的相关性。
方法
根据是否存在 NAFLD 和/或 2 型糖尿病（T2DM）将参与者分为四组。采用定量聚合酶链反应分析检测血清 miR-29a-c 水平。评估 miR-29a-c 与 NAFLD 的相关性。
结果
血清 miR-29b 与 NAFLD 呈正相关（优势比[OR]2.04[1.16-3.58]，P=0.013），但 miR-29a 或 miR-29c 与 NAFLD 无关。此外，年龄、血清甘油三酯和空腹血糖（FPG）水平与 miR-29b 独立相关（β±标准误[SE]0.004±0.002，P=0.019 对年龄；β±SE0.110±0.054，P=0.042 对甘油三酯；β±SE0.389±0.161，P=0.016 对 FPG）。校正年龄、性别和体重指数后，miR-29b 水平与肝内脂质含量呈正相关（β±SE6.055±2.630，P=0.024）。
结论
在中国人群中，血清 miR-29b 与肝内脂质含量和 NAFLD 相关。
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